Bilateral population receptive fields in congenital hemihydranencephaly

Fracasso, A. , Koenraads, Y., Porro, G.L. and Dumoulin, S.O. (2016) Bilateral population receptive fields in congenital hemihydranencephaly. Ophthalmic and Physiological Optics, 36(3), pp. 324-334. (doi:10.1111/opo.12294) (PMID:27112226)

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Abstract

Purpose: Congenital hemihydranencephaly (HH) is a very rare disorder characterised by prenatal near-complete unilateral loss of the cerebral cortex. We investigated a patient affected by congenital right HH whose visual field extended significantly into the both visual hemifields, suggesting a reorganisation of the remaining left visual hemisphere. We examined the early visual cortex reorganisation using functional MRI (7T) and population receptive field (pRF) modelling. Methods: Data were acquired by means of a 7T MRI while the patient affected by HH viewed conventional population receptive field mapping stimuli. Two possible pRF reorganisation schemes were evaluated: where every cortical location processed information from either (i) a single region of the visual field or (ii) from two bilateral regions of the visual field. Results: In the patient affected by HH, bilateral pRFs in single cortical locations of the remaining hemisphere were found. In addition, using this specific pRF reorganisation scheme, the biologically known relationship between pRF size and eccentricity was found. Conclusions: Bilateral pRFs were found in the remaining left hemisphere of the patient affected by HH, indicating reorganisation of intra-cortical wiring of the early visual cortex and confirming brain plasticity and reorganisation after an early cerebral damage in humans.

Item Type:Articles
Additional Information:This work was supported by a Netherlands Organisationfor Scientific Research (NWO) Grant 433.09.223 (S.O.D.).
Keywords:Adult, comparative study, diagnostic imaging, eye movement, human, hydranencephaly, male, nuclear magnetic resonance imaging, pathophysiology, photostimulation, physiology, procedures, visual cortex, visual field, adult, eye movements, humans, hydranencephaly, magnetic resonance imaging, male, photic stimulation, visual cortex, visual fields.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fracasso, Dr Alessio
Authors: Fracasso, A., Koenraads, Y., Porro, G.L., and Dumoulin, S.O.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Ophthalmic and Physiological Optics
Publisher:Wiley
ISSN:0275-5408
ISSN (Online):1475-1313
Published Online:25 April 2016

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