Detailed T1-weighted profiles from the human cortex measured in vivo at 3 Tesla MRI

Ferguson, B., Petridou, N., Fracasso, A. , van Den Heuvel, M.P., Brouwer, R.M., Hulshoff Pol, H.E., Kahn, R.S. and Mandl, R.C.W. (2018) Detailed T1-weighted profiles from the human cortex measured in vivo at 3 Tesla MRI. Neuroinformatics, 16(2), pp. 181-196. (doi:10.1007/s12021-018-9356-2) (PMID:29352389) (PMCID:PMC5984962)

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Abstract

Studies into cortical thickness in psychiatric diseases based on T1-weighted MRI frequently report on aberrations in the cerebral cortex. Due to limitations in image resolution for studies conducted at conventional MRI field strengths (e.g. 3 Tesla (T)) this information cannot be used to establish which of the cortical layers may be implicated. Here we propose a new analysis method that computes one high-resolution average cortical profile per brain region extracting myeloarchitectural information from T1-weighted MRI scans that are routinely acquired at a conventional field strength. To assess this new method, we acquired standard T1-weighted scans at 3 T and compared them with state-of-the-art ultra-high resolution T1-weighted scans optimised for intracortical myelin contrast acquired at 7 T. Average cortical profiles were computed for seven different brain regions. Besides a qualitative comparison between the 3 T scans, 7 T scans, and results from literature, we tested if the results from dynamic time warping-based clustering are similar for the cortical profiles computed from 7 T and 3 T data. In addition, we quantitatively compared cortical profiles computed for V1, V2 and V7 for both 7 T and 3 T data using a priori information on their relative myelin concentration. Although qualitative comparisons show that at an individual level average profiles computed for 7 T have more pronounced features than 3 T profiles the results from the quantitative analyses suggest that average cortical profiles computed from T1-weighted scans acquired at 3 T indeed contain myeloarchitectural information similar to profiles computed from the scans acquired at 7 T. The proposed method therefore provides a step forward to study cortical myeloarchitecture in vivo at conventional magnetic field strength both in health and disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fracasso, Dr Alessio
Authors: Ferguson, B., Petridou, N., Fracasso, A., van Den Heuvel, M.P., Brouwer, R.M., Hulshoff Pol, H.E., Kahn, R.S., and Mandl, R.C.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Neuroinformatics
Publisher:Humana Press
ISSN:1539-2791
ISSN (Online):1559-0089
Published Online:19 January 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Neuroinformatics 16(2): 181-196
Publisher Policy:Reproduced under a Creative Commons License

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