Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Horsburgh, K. et al. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868. (doi:10.1042/CS20171620) (PMID:29712883)

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Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

Item Type:Articles
Additional Information:This work was supported by the ARUK, ARUK Scotland network; Alzheimer's Society; BHF and BHF Cardiovascular centre; MRC-DPUK; the Royal Society Edinburgh; Stroke Association and Fondation Leducq.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Goense, Dr Jozien and Harvey, Dr Adam and McCabe, Dr Chris and Van Agtmael, Dr Tom and Macrae, Professor I Mhairi and Work, Dr Lorraine and Miller, Dr Alyson and Quinn, Dr Terence and Touyz, Professor Rhian
Authors: Horsburgh, K., Wardlaw, J. M., Van Agtmael, T., Allan, S. M., Ashford, M. L.J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A., Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C.R., and Work, L. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Science and Engineering > School of Psychology
Journal Name:Clinical Science
Publisher:Portland Press
ISSN:0143-5221
ISSN (Online):1470-8736
Published Online:30 April 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Clinical Science 132(8):851-868
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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