Aasen, T., Johnstone, S., Vidal-Brime, L., Lynn, K. S. and Koval, M. (2018) Connexins: synthesis, post-translational modifications, and trafficking in health and disease. International Journal of Molecular Sciences, 19(5), 1296. (doi: 10.3390/ijms19051296) (PMID:29701678)
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Abstract
Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability, and function. Here, we summarize these key regulatory events, with emphasis on how these affect connexin multifunctionality in health and disease.
| Item Type: | Articles |
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| Additional Information: | Trond Aasen acknowledges support from Instituto de Salud Carlos III grants PI13/00763, PI16/00772 and CPII16/00042, co-financed by the European Regional Development Fund (ERDF). Supported by NIH R01-AA025854 and R01-HL137112 (Michael Koval) and F31-HL139109 (K. Sabrina Lynn). |
| Keywords: | Connexins, gap junctions, post-translational modifications, trafficking, transcription, translation. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Johnstone, Dr Scott |
| Authors: | Aasen, T., Johnstone, S., Vidal-Brime, L., Lynn, K. S., and Koval, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | International Journal of Molecular Sciences |
| Publisher: | MDPI |
| ISSN: | 1661-6596 |
| ISSN (Online): | 1422-0067 |
| Published Online: | 26 April 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in International Journal of Molecular Sciences 19(5): 1296 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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