Autoimmune neurological conditions associated with Zika virus infection

Acosta-Ampudia, Y., Monsalve, D. M., Castillo-Medina, L. F., Rodríguez, Y., Pacheco, Y., Halstead, S., Willison, H. J. , Anaya, J.-M. and Ramírez-Santana, C. (2018) Autoimmune neurological conditions associated with Zika virus infection. Frontiers in Molecular Neuroscience, 11, 116. (doi: 10.3389/fnmol.2018.00116) (PMID:29695953) (PMCID:PMC5904274)

Abstract

Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids. ZIKV infection is often asymptomatic and those with symptoms present minor illness after 3 to 12 days of incubation, characterized by a mild and self-limiting disease with low-grade fever, conjunctivitis, widespread pruritic maculopapular rash, arthralgia and myalgia. ZIKV has been linked to a number of central and peripheral nervous system injuries such as Guillain-Barré syndrome (GBS), transverse myelitis (TM), meningoencephalitis, ophthalmological manifestations, and other neurological complications. Nevertheless, mechanisms of host-pathogen neuro-immune interactions remain incompletely elucidated. This review provides a critical discussion about the possible mechanisms underlying the development of autoimmune neurological conditions associated with Zika virus infection.

• Item Type: Articles
• Additional Information: This work was supported by Universidad del Rosario (ABN011) and Colciencias (747-2016), Bogota, Colombia.
• Keywords: Guillain-Barré syndrome, Transverse myelitis, Zika virus, autoimmunity, molecular mimicry
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Halstead, Dr Susan and Willison, Professor Hugh
• Authors: Acosta-Ampudia, Y., Monsalve, D. M., Castillo-Medina, L. F., Rodríguez, Y., Pacheco, Y., Halstead, S., Willison, H. J., Anaya, J.-M., and Ramírez-Santana, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Frontiers in Molecular Neuroscience
• Publisher: Frontiers Media
• ISSN: 1662-5099
• ISSN (Online): 1662-5099
• Published Online: 11 April 2018
• Copyright Holders: Copyright © 2018 Acosta-Ampudia, Monsalve, Castillo-Medina, Rodríguez, Pacheco, Halstead, Willison, Anaya and Ramírez-Santana
• First Published: First published in Frontiers in Molecular Neuroscience 11:116
• Publisher Policy: Reproduced under a Creative Commons License