Autoimmune neurological conditions associated with Zika virus infection

Acosta-Ampudia, Y., Monsalve, D. M., Castillo-Medina, L. F., Rodríguez, Y., Pacheco, Y., Halstead, S., Willison, H. J. , Anaya, J.-M. and Ramírez-Santana, C. (2018) Autoimmune neurological conditions associated with Zika virus infection. Frontiers in Molecular Neuroscience, 11, 116. (doi: 10.3389/fnmol.2018.00116) (PMID:29695953) (PMCID:PMC5904274)

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Abstract

Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids. ZIKV infection is often asymptomatic and those with symptoms present minor illness after 3 to 12 days of incubation, characterized by a mild and self-limiting disease with low-grade fever, conjunctivitis, widespread pruritic maculopapular rash, arthralgia and myalgia. ZIKV has been linked to a number of central and peripheral nervous system injuries such as Guillain-Barré syndrome (GBS), transverse myelitis (TM), meningoencephalitis, ophthalmological manifestations, and other neurological complications. Nevertheless, mechanisms of host-pathogen neuro-immune interactions remain incompletely elucidated. This review provides a critical discussion about the possible mechanisms underlying the development of autoimmune neurological conditions associated with Zika virus infection.

Item Type:Articles
Additional Information:This work was supported by Universidad del Rosario (ABN011) and Colciencias (747-2016), Bogota, Colombia.
Keywords:Guillain-Barré syndrome, Transverse myelitis, Zika virus, autoimmunity, molecular mimicry
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Halstead, Dr Susan and Willison, Professor Hugh
Authors: Acosta-Ampudia, Y., Monsalve, D. M., Castillo-Medina, L. F., Rodríguez, Y., Pacheco, Y., Halstead, S., Willison, H. J., Anaya, J.-M., and Ramírez-Santana, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Molecular Neuroscience
Publisher:Frontiers Media
ISSN:1662-5099
ISSN (Online):1662-5099
Published Online:11 April 2018
Copyright Holders:Copyright © 2018 Acosta-Ampudia, Monsalve, Castillo-Medina, Rodríguez, Pacheco, Halstead, Willison, Anaya and Ramírez-Santana
First Published:First published in Frontiers in Molecular Neuroscience 11:116
Publisher Policy:Reproduced under a Creative Commons License

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