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Essential hypertension: rational pharmacotherapy

Connell, J. M.C. (1986) Essential hypertension: rational pharmacotherapy. Trends in Pharmacological Sciences, 7 (10). pp. 412-418. ISSN 0165-6147 (doi:10.1016/0165-6147(86)90404-9)

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Publisher's URL: http://dx.doi.org/10.1016/0165-6147(86)90404-9

Abstract

The mechanism resulting in the development of essential hypertension is unclear and specific pharmacological treatment may not therefore be available. In this review, John Connell considers the principal hypotheses to account for the disorder, which include whole body autoregulation, inhibition of active Na+ efflux from vascular smooth muscle cells, and vascular hypertrophy (whether primary or secondary) and examines the way in which currently available drugs interact with these potential mechanisms.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Connell, Prof John
Authors: Connell, J. M.C.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Trends in Pharmacological Sciences
Publisher:Elsevier
ISSN:0165-6147
ISSN (Online):1873-3735
Published Online:21 February 2003

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