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Publisher's URL: http://dx.doi.org/10.1016/0165-6147(86)90404-9
The mechanism resulting in the development of essential hypertension is unclear and specific pharmacological treatment may not therefore be available. In this review, John Connell considers the principal hypotheses to account for the disorder, which include whole body autoregulation, inhibition of active Na+ efflux from vascular smooth muscle cells, and vascular hypertrophy (whether primary or secondary) and examines the way in which currently available drugs interact with these potential mechanisms.
|Glasgow Author(s) Enlighten ID:||Connell, Prof John|
|Authors:||Connell, John M.C.|
|College/School:||College of Medical Veterinary and Life Sciences|
|Journal Name:||Trends in Pharmacological Sciences|
|Published Online:||21 February 2003|