Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank

Wyse, C. A. et al. (2018) Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank. Annals of Medicine, 50(5), pp. 410-419. (doi:10.1080/07853890.2018.1472389) (PMID:29724143)

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Abstract

Introduction: The risk of mortality from cardiovascular disease (CVD) is higher in wintertime throughout the world, but it is not known if this reflects annual changes in diet or lifestyle, or an endogenous photoperiodic mechanism that is sensitive to changes in daylength. Methods: Phenotypic data on cardiometabolic and lifestyle factors were collected throughout a 4 year time period from 502,642 middle-aged participants in UK Biobank. To assess the impact of seasonal environmental changes on cardiovascular risk factors, we linked these data to the outdoor temperature and day length at the time of assessment. Self-reported information on physical activity, diet and disease status were used to adjust for confounding factors related to health and lifestyle. Results: Mortality related to CVD was higher in winter, as were risk factors for this condition including blood pressure, markers of inflammation and BMI. These seasonal rhythms were significantly related to day length after adjustment for other factors that might affect seasonality including physical activity, diet and outdoor temperature. Conclusions: The risk of CVD may be modulated by day length at temperate latitudes, and the implications of seasonality should be considered in all studies of human cardiometabolic health.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ward, Mr Joey and Celis, Dr Carlos and Wyse, Dr Cathy and Gill, Professor Jason and Smith, Professor Daniel and Pell, Professor Jill and Biello, Professor Stephany and Mackay, Dr Daniel and Bailey, Dr Mark and Lyall, Dr Donald
Authors: Wyse, C. A., Celis Morales, C. A., Ward, J., Lyall, D., Smith, D. J., Mackay, D., Curtis, A. M., Bailey, M. E., Biello, S., Gill, J. M.R., and Pell, J.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Science and Engineering > School of Psychology
Journal Name:Annals of Medicine
Publisher:Taylor & Francis
ISSN:0785-3890
ISSN (Online):1365-2060
Published Online:03 May 2018
Copyright Holders:Copyright © 2018 Taylor & Francis
First Published:First published in Annals of Medicine 50(5):410-419
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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