Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank

Wyse, C. A. et al. (2018) Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK Biobank. Annals of Medicine, 50(5), pp. 410-419. (doi: 10.1080/07853890.2018.1472389) (PMID:29724143)

Abstract

Introduction: The risk of mortality from cardiovascular disease (CVD) is higher in wintertime throughout the world, but it is not known if this reflects annual changes in diet or lifestyle, or an endogenous photoperiodic mechanism that is sensitive to changes in daylength. Methods: Phenotypic data on cardiometabolic and lifestyle factors were collected throughout a 4 year time period from 502,642 middle-aged participants in UK Biobank. To assess the impact of seasonal environmental changes on cardiovascular risk factors, we linked these data to the outdoor temperature and day length at the time of assessment. Self-reported information on physical activity, diet and disease status were used to adjust for confounding factors related to health and lifestyle. Results: Mortality related to CVD was higher in winter, as were risk factors for this condition including blood pressure, markers of inflammation and BMI. These seasonal rhythms were significantly related to day length after adjustment for other factors that might affect seasonality including physical activity, diet and outdoor temperature. Conclusions: The risk of CVD may be modulated by day length at temperate latitudes, and the implications of seasonality should be considered in all studies of human cardiometabolic health.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gill, Professor Jason and Smith, Professor Daniel and Mackay, Professor Daniel and Biello, Professor Stephany and Bailey, Dr Mark and Ward, Dr Joey and Celis, Dr Carlos and Wyse, Dr Cathy and Pell, Professor Jill and Lyall, Dr Donald
• Authors: Wyse, C. A., Celis Morales, C. A., Ward, J., Lyall, D., Smith, D. J., Mackay, D., Curtis, A. M., Bailey, M. E., Biello, S., Gill, J. M.R., and Pell, J.P.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health; College of Medical Veterinary and Life Sciences > School of Life Sciences; College of Science and Engineering > School of Psychology; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences; College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Annals of Medicine
• Publisher: Taylor & Francis
• ISSN: 0785-3890
• ISSN (Online): 1365-2060
• Published Online: 03 May 2018
• Copyright Holders: Copyright © 2018 Taylor & Francis
• First Published: First published in Annals of Medicine 50(5):410-419
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher