Earth-abundant mixed-metal catalysts for hydrocarbon oxygenation

Pankhurst, J. R., Curcio, M., Sproules, S. , Lloyd-Jones, G. C. and Love, J. B. (2018) Earth-abundant mixed-metal catalysts for hydrocarbon oxygenation. Inorganic Chemistry, 57(10), pp. 5915-5928. (doi:10.1021/acs.inorgchem.8b00420) (PMID:29708740)

Pankhurst, J. R., Curcio, M., Sproules, S. , Lloyd-Jones, G. C. and Love, J. B. (2018) Earth-abundant mixed-metal catalysts for hydrocarbon oxygenation. Inorganic Chemistry, 57(10), pp. 5915-5928. (doi:10.1021/acs.inorgchem.8b00420) (PMID:29708740)

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Abstract

The oxygenation of aliphatic and aromatic hydrocarbons using earth-abundant Fe and Cu catalysts and “green” oxidants such as hydrogen peroxide is becoming increasingly important to atom-economical chemical processing. In light of this, we describe that dinuclear CuII complexes of pyrrolic Schiff-base macrocycles, in combination with ferric chloride (FeCl3), catalyze the oxygenation of π-activated benzylic substrates with hydroperoxide oxidants at room temperature and low loadings, representing a novel design in oxidation catalysis. Mass spectrometry and extended X-ray absorption fine structure analysis indicate that a cooperative action between CuII and FeIII occurs, most likely because of the interaction of FeCl3 or FeCl4– with the dinuclear CuII macrocycle. Voltammetric measurements highlight a modulation of both CuII and FeIII redox potentials in this adduct, but electron paramagnetic resonance spectroscopy indicates that any Cu–Fe intermetallic interaction is weak. High ketone/alcohol product ratios, a small reaction constant (Hammett analysis), and small kinetic isotope effect for H-atom abstraction point toward a free-radical reaction. However, the lack of reactivity with cyclohexane, oxidation of 9,10-dihydroanthracene, oxygenation by the hydroperoxide MPPH (radical mechanistic probe), and oxygenation in dinitrogen-purge experiments indicate a metal-based reaction. Through detailed reaction monitoring and associated kinetic modeling, a network of oxidation pathways is proposed that includes “well-disguised” radical chemistry via the formation of metal-associated radical intermediates.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sproules, Dr Stephen
Authors: Pankhurst, J. R., Curcio, M., Sproules, S., Lloyd-Jones, G. C., and Love, J. B.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Inorganic Chemistry
Publisher:American Chemical Society
ISSN:0020-1669
ISSN (Online):1520-510X
Published Online:30 April 2018
Copyright Holders:Copyright © 2018 American Chemical Society
First Published:First published in Inorganic Chemistry 57(10): 5915-5928
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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