Kumawat, A. K., Yu, C., Mann, E. A., Schridde, A., Finnemann, S. C. and Mowat, A. M. (2018) Expression and characterisation of αvβ5 integrin on intestinal macrophages. European Journal of Immunology, 48(7), pp. 1181-1187. (doi: 10.1002/eji.201747318) (PMID:29676784) (PMCID:PMC6207937)
|
Text
161248.pdf - Accepted Version 1MB |
Abstract
Macrophages play a crucial role in maintaining homeostasis in the intestine, but the underlying mechanisms have not yet been elucidated fully. Here we show for the first time that mature intestinal macrophages in mouse colon and small intestine express high levels of αvβ5 integrin, which acts as a receptor for the uptake of apoptotic cells and can activate molecules involved in several aspects of tissue homeostasis such as angiogenesis and remodelling of the extracellular matrix. αvβ5 is not expressed by other immune cells in the intestine, is already present on intestinal macrophages soon after birth, and its expression is not dependent on the microbiota. In adults, αvβ5 induces the differentiation of monocytes in response to the local environment and it confers intestinal macrophages with the ability to promote engulfment of apoptotic cells via engagement of the bridging molecule milk fat globule EGF‐like molecule 8. In the absence of αvβ5, there are fewer monocytes in the mucosa and mature intestinal macrophages have decreased expression of metalloproteases and interleukin 10. Mice lacking αvβ5 on haematopoietic cells show increased susceptibility to chemical colitis and we conclude that αvβ5 contributes to the tissue repair by regulating the homeostatic properties of intestinal macrophages.
| Item Type: | Articles |
|---|---|
| Keywords: | Immunology, immunology and allergy. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mowat, Professor Allan and Schridde, Ms Anika and Kumawat, Dr Ashok and Mann, Dr Elizabeth |
| Authors: | Kumawat, A. K., Yu, C., Mann, E. A., Schridde, A., Finnemann, S. C., and Mowat, A. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | European Journal of Immunology |
| Publisher: | Wiley |
| ISSN: | 0014-2980 |
| ISSN (Online): | 1521-4141 |
| Published Online: | 20 April 2018 |
| Copyright Holders: | Copyright © 2018 Wiley-VCH Verlag GmbH and Co. KGaA |
| First Published: | First published in European Journal of Immunology 48(7): 1181-1187 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information