Generation Scotland: the Scottish family health study; a new resource for researching genes and heritability

Smith, B.H. et al. (2006) Generation Scotland: the Scottish family health study; a new resource for researching genes and heritability. BMC Medical Genetics, 7, p. 74. (doi:10.1186/1471-2350-7-74)

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Abstract

Background: Generation Scotland: the Scottish Family Health Study aims to identify genetic variants accounting for variation in levels of quantitative traits underlying the major common complex diseases (such as cardiovascular disease, cognitive decline, mental illness) in Scotland. Methods/Design: Generation Scotland will recruit a family-based cohort of up to 50,000 individuals (comprising siblings and parent-offspring groups) across Scotland. It will be a six-year programme, beginning in Glasgow and Tayside in the first two years (Phase 1) before extending to other parts of Scotland in the remaining four years (Phase 2). In Phase 1, individuals aged between 35 and 55 years, living in the East and West of Scotland will be invited to participate, along with at least one (and preferably more) siblings and any other first degree relatives aged 18 or over. The total initial sample size will be 15,000 and it is planned that this will increase to 50,000 in Phase 2. All participants will be asked to contribute blood samples from which DNA will be extracted and stored for future investigation. The information from the DNA, along with answers to a life-style and medical history questionnaire, clinical and biochemical measurements taken at the time of donation, and subsequent health developments over the life course (traced through electronic health records) will be stored and used for research purposes. In addition, a detailed public consultation process will begin that will allow respondents' views to shape and develop the study. This is an important aspect to the research, and forms the continuation of a long-term parallel engagement process. Discussion: As well as gene identification, the family-based study design will allow measurement of the heritability and familial aggregation of relevant quantitative traits, and the study of how genetic effects may vary by parent-of-origin. Long-term potential outcomes of this research include the targeting of disease prevention and treatment, and the development of screening tools based on the new genetic information. This study approach is complementary to other population-based genetic epidemiology studies, such as UK Biobank, which are established primarily to characterise genes and genetic risk in the population.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lindsay, Dr Robert and Connor, Mrs Margaret and Dominiczak, Professor Anna and Connell, Professor John and Pell, Professor Jill and Fitzpatrick, Dr Bridie and Watt, Professor Graham and Ford, Professor Ian
Authors: Smith, B.H., Campbell, H., Blackwood, D., Connell, J., Connor, M., Deary, I.J., Dominiczak, A.F., Fitzpatrick, B., Ford, I., Jackson, C., Haddow, G., Kerr, S., Lindsay, R., McGilchrist, M., Morton, R., Murray, G., Palmer, C.N., Pell, J.P., Ralston, S.H., St Clair, D., Sullivan, F., Watt, G.C.M., Wolf, R., Wright, A., Porteous, D., and Morris, A.D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Centre for Population and Health Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Nursing and Health Care
Journal Name:BMC Medical Genetics
Publisher:BioMed Central Ltd.
ISSN:1471-2350
Published Online:02 October 2006
Copyright Holders:Copyright © 2006 BioMed Central Ltd.
First Published:First published in BMC Medical Genetics 7: 74
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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