A rapid (differential) effect of rosuvastatin and atorvastatin on high-sensitivity cardiac Troponin-I in subjects with stable cardiovascular disease

Bodde, M. C., Welsh, P. , Bergheanu, S. C., Lijfering, W. M., Mertens, B., Liem, A.-H., van der Laarse, A., Sattar, N. and Jukema, J.W. (2018) A rapid (differential) effect of rosuvastatin and atorvastatin on high-sensitivity cardiac Troponin-I in subjects with stable cardiovascular disease. Clinical Pharmacology and Therapeutics, 104(2), pp. 311-316. (doi:10.1002/cpt.1095) (PMID:29672821)

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Abstract

Serum troponin within the normal range is an emerging predictor of cardiovascular mortality. We aimed to determine how rapidly high‐sensitivity troponin‐I (hs‐cTnI) levels are lowered by statin therapy in patients with stable cardiovascular disease. In the RADAR substudy, patients were randomized to atorvastatin 20 mg/day (n = 39) or rosuvastatin 10 mg/day (n = 39) and up‐titrated at 6‐week intervals to 80 mg of atorvastatin or 40 mg of rosuvastatin. Hs‐cTnI concentrations were measured at baseline and at 6 and 18 weeks of follow‐up. Statin treatment resulted in a mean change of serum hs‐cTnI of –8.2% (P = 0.010) after 6 weeks and –12.3% (P = 0.001) after 18 weeks. After 18 weeks, hs‐cTnI levels were lowered by 21.8% with atorvastatin and by 4.1% with rosuvastatin (P = 0.001 and P = 0.133, respectively). During statin therapy, serum hs‐cTnI levels decreased rapidly within weeks of treatment, suggesting an effect beyond long‐term atherosclerosis regression. Mechanisms that mediate this effect require further study.

Item Type:Articles
Keywords:Pharmacology (medical), pharmacology.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sattar, Professor Naveed and Welsh, Dr Paul
Authors: Bodde, M. C., Welsh, P., Bergheanu, S. C., Lijfering, W. M., Mertens, B., Liem, A.-H., van der Laarse, A., Sattar, N., and Jukema, J.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Clinical Pharmacology and Therapeutics
Publisher:Wiley
ISSN:0009-9236
ISSN (Online):1532-6535
Published Online:19 April 2018
Copyright Holders:Copyright © 2018 American Society for Clinical Pharmacology and Therapeutics
First Published:First published in Clinical Pharmacology and Therapeutics 104(2): 311-316
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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