Bodde, M. C., Welsh, P. , Bergheanu, S. C., Lijfering, W. M., Mertens, B., Liem, A.-H., van der Laarse, A., Sattar, N. and Jukema, J.W. (2018) A rapid (differential) effect of rosuvastatin and atorvastatin on high-sensitivity cardiac Troponin-I in subjects with stable cardiovascular disease. Clinical Pharmacology and Therapeutics, 104(2), pp. 311-316. (doi: 10.1002/cpt.1095) (PMID:29672821)
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Abstract
Serum troponin within the normal range is an emerging predictor of cardiovascular mortality. We aimed to determine how rapidly high‐sensitivity troponin‐I (hs‐cTnI) levels are lowered by statin therapy in patients with stable cardiovascular disease. In the RADAR substudy, patients were randomized to atorvastatin 20 mg/day (n = 39) or rosuvastatin 10 mg/day (n = 39) and up‐titrated at 6‐week intervals to 80 mg of atorvastatin or 40 mg of rosuvastatin. Hs‐cTnI concentrations were measured at baseline and at 6 and 18 weeks of follow‐up. Statin treatment resulted in a mean change of serum hs‐cTnI of –8.2% (P = 0.010) after 6 weeks and –12.3% (P = 0.001) after 18 weeks. After 18 weeks, hs‐cTnI levels were lowered by 21.8% with atorvastatin and by 4.1% with rosuvastatin (P = 0.001 and P = 0.133, respectively). During statin therapy, serum hs‐cTnI levels decreased rapidly within weeks of treatment, suggesting an effect beyond long‐term atherosclerosis regression. Mechanisms that mediate this effect require further study.
| Item Type: | Articles |
|---|---|
| Keywords: | Pharmacology (medical), pharmacology. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sattar, Professor Naveed and Welsh, Professor Paul |
| Authors: | Bodde, M. C., Welsh, P., Bergheanu, S. C., Lijfering, W. M., Mertens, B., Liem, A.-H., van der Laarse, A., Sattar, N., and Jukema, J.W. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Clinical Pharmacology and Therapeutics |
| Publisher: | Wiley |
| ISSN: | 0009-9236 |
| ISSN (Online): | 1532-6535 |
| Published Online: | 19 April 2018 |
| Copyright Holders: | Copyright © 2018 American Society for Clinical Pharmacology and Therapeutics |
| First Published: | First published in Clinical Pharmacology and Therapeutics 104(2): 311-316 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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