Remnants of an ancient deltaretrovirus in the genomes of horseshoe aats (Rhinolophidae)

Hron, T., Farkašová, H., Gifford, R. J. , Benda, P., Hulva, P., Görföl, T., Pačes, J. and Elleder, D. (2018) Remnants of an ancient deltaretrovirus in the genomes of horseshoe aats (Rhinolophidae). Viruses, 10(4), 185. (doi:10.3390/v10040185) (PMID:29642581) (PMCID:PMC5923479)

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Abstract

Endogenous retrovirus (ERV) sequences provide a rich source of information about the long-term interactions between retroviruses and their hosts. However, most ERVs are derived from a subset of retrovirus groups, while ERVs derived from certain other groups remain extremely rare. In particular, only a single ERV sequence has been identified that shows evidence of being related to an ancient , despite the large number of vertebrate genome sequences now available. In this report, we identify a second example of an ERV sequence putatively derived from a past deltaretroviral infection, in the genomes of several species of horseshoe bats (Rhinolophidae). This sequence represents a fragment of viral genome derived from a single integration. The time of the integration was estimated to be 11-19 million years ago. This finding, together with the previously identified endogenous in long-fingered bats (Miniopteridae), suggest a close association of bats with ancient deltaretroviruses.

Item Type:Articles
Additional Information:The work was supported by the Czech Ministry of Education, Youth and Sports under the program NAVRAT (LK11215). The work was also institutionally supported by RVO:68378050. Access to computing and storage facilities was provided by ELIXIR CZ research infrastructure project (MEYS Grant LM2015047). Robert J. Gifford was supported by a grant from the UK Medical Research Council (No. MC_UU_12014/10). This study was also supported by the Ministry of Culture of the Czech Republic (DKRVO 2018/14, 00023272). Part of the samples was collected with the help of the Hungarian Scientific Research Fund (OTKA K112440).
Keywords:Deltaretrovirus, bats, endogenous retrovirus, evolution, genomics, retrovirus.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gifford, Dr Robert
Authors: Hron, T., Farkašová, H., Gifford, R. J., Benda, P., Hulva, P., Görföl, T., Pačes, J., and Elleder, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Viruses
Publisher:MDPI
ISSN:1999-4915
ISSN (Online):1999-4915
Published Online:10 April 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Viruses 10(4):185
Publisher Policy:Reproduced under a Creative Commons License
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