de Souza, W. M., Romeiro, M. F., Sabino-Santos, G., Maia, F. G. M., Fumagalli, M. J., Modha, S. , Nunes, M. R. T., Murcia, P. R. and Figueiredo, L. T. M. (2018) Novel orthohepeviruses in wild rodents from São Paulo State, Brazil. Virology, 519, pp. 12-16. (doi: 10.1016/j.virol.2018.03.025) (PMID:29627586) (PMCID:PMC5998382)
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Abstract
The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.
| Item Type: | Articles |
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| Keywords: | Hepatitis E virus, hepeviridae, orthohepevirus, rodent-borne viruses, viral hepatitis. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Modha, Ms Sejal and Souza, Mr William and Murcia, Professor Pablo |
| Authors: | de Souza, W. M., Romeiro, M. F., Sabino-Santos, G., Maia, F. G. M., Fumagalli, M. J., Modha, S., Nunes, M. R. T., Murcia, P. R., and Figueiredo, L. T. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Virology |
| Publisher: | Elsevier |
| ISSN: | 0042-6822 |
| ISSN (Online): | 1096-0341 |
| Published Online: | 05 April 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Virology 519:12-16 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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