Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

de Souza, W. M., Romeiro, M. F., Sabino-Santos, G., Maia, F. G. M., Fumagalli, M. J., Modha, S. , Nunes, M. R. T., Murcia, P. R. and Figueiredo, L. T. M. (2018) Novel orthohepeviruses in wild rodents from São Paulo State, Brazil. Virology, 519, pp. 12-16. (doi: 10.1016/j.virol.2018.03.025) (PMID:29627586) (PMCID:PMC5998382)

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Abstract

The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

Item Type:Articles
Keywords:Hepatitis E virus, hepeviridae, orthohepevirus, rodent-borne viruses, viral hepatitis.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Modha, Ms Sejal and Souza, Mr William and Murcia, Professor Pablo
Authors: de Souza, W. M., Romeiro, M. F., Sabino-Santos, G., Maia, F. G. M., Fumagalli, M. J., Modha, S., Nunes, M. R. T., Murcia, P. R., and Figueiredo, L. T. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Virology
Publisher:Elsevier
ISSN:0042-6822
ISSN (Online):1096-0341
Published Online:05 April 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Virology 519:12-16
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
709011Quinquennial Core FundsMassimo PalmariniMedical Research Council (MRC)MC_UU_12014/9MVLS III - CENTRE FOR VIRUS RESEARCH