Fecal Enterobacteriales enrichment is associated with increased in vivo intestinal permeability in humans

Pedersen, C. et al. (2018) Fecal Enterobacteriales enrichment is associated with increased in vivo intestinal permeability in humans. Physiological Reports, 6(7), e13649. (doi:10.14814/phy2.13649) (PMID:29611319) (PMCID:PMC5880877)

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Abstract

Type 2 diabetes (T2D) has been linked with increased intestinal permeability, but the clinical significance of this phenomenon remains unknown. The objective of this study was to investigate the potential link between glucose control, intestinal permeability, diet and intestinal microbiota in patients with T2D. Thirty‐two males with well‐controlled T2D and 30 age‐matched male controls without diabetes were enrolled in a case–control study. Metabolic parameters, inflammatory markers, endotoxemia, and intestinal microbiota in individuals subdivided into high (HP) and normal (LP) colonic permeability groups, were the main outcomes. In T2D, the HP group had significantly higher fasting glucose (P = 0.034) and plasma nonesterified fatty acid levels (P = 0.049) compared with the LP group. Increased colonic permeability was also linked with altered abundances of selected microbial taxa. The microbiota of both T2D and control HP groups was enriched with Enterobacteriales. In conclusion, high intestinal permeability was associated with poorer fasting glucose control in T2D patients and changes in some microbial taxa in both T2D patients and nondiabetic controls. Therefore, enrichment in the gram‐negative order Enterobacteriales may characterize impaired colonic permeability prior to/independently from a disruption in glucose tolerance.

Item Type:Articles
Additional Information:The research was supported by the National Institute for Health Research (NIHR) Clinical Research Network (CRN): Kent, Surrey and Sussex. UZI is funded by a NERC fellowship NE/L011956/1. PDC is senior research associate from the FRS‐FNRS in Belgium. PDC is the recipient of grants from FNRS, PDR (Projet de Recherche, convention: T.0138.14). This work was supported by the FRFS‐WELBIO under grant: WELBIO‐CR‐2012S‐02R, the Funds Baillet Latour (Grant for Medical Research 2015), and ERC Starting Grant 2013 (Starting grant 336452‐ENIGMO). This study was funded by an EFSD clinical research grant.
Keywords:Endotoxemia, glucose control, intestinal microbiota, intestinal permeability, type 2 diabetes
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ijaz, Dr Umer Zeeshan
Authors: Pedersen, C., Ijaz, U. Z., Gallagher, E., Horton, F., Ellis, R. J., Jaiyeola, E., Duparc, T., Russell-Jones, D., Hinton, P., Cani, P. D., La Ragione, R. M., and Robertson, M. D.
College/School:College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Physiological Reports
Publisher:Physiological Reports
ISSN:2051-817X
ISSN (Online):2051-817X
Published Online:02 April 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Physiological Reports 6)7):e13649
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
652771Understanding microbial community through in situ environmental 'omic data synthesisUmer Zeeshan IjazNatural Environment Research Council (NERC)NE/L011956/1ENG - ENGINEERING INFRASTRUCTURE & ENVIR