Ethnic considerations in pharmacogenetic studies - In reply

Marsh, S., Paul, J. , McLeod, H.L. and Brown, R. (2008) Ethnic considerations in pharmacogenetic studies - In reply. Journal of Clinical Oncology, 26(10), pp. 1767-1768. (doi:10.1200/JCO.2007.15.8212)

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Branford et al correctly highlight that ethnic variability in allele frequencies can be a major source of variability between pharmacogenetic studies. Indeed, as we discuss in the original publication,1 population differences along with other differences between studies (eg, sample size, tumor type, and treatment regimen) are all possible causes for the lack of replication of previous findings.

Item Type:Articles (Letter)
Glasgow Author(s) Enlighten ID:Paul, Mr James
Authors: Marsh, S., Paul, J., McLeod, H.L., and Brown, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Clinical Oncology

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