The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation

Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J. and Fuller, W. (2011) The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. Journal of Biological Chemistry, 286(41), pp. 36020-36031. (doi:10.1074/jbc.M111.282145) (PMID:21868384) (PMCID:PMC3195638)

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Abstract

Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart. Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump. Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump. Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.

Item Type:Articles
Additional Information:This work was supported by grants from the British Heart Foundation (RG/07/001 to W. F. and M. J. S.), the Medical Research Council (G0700903 to W. F.), and Tenovus Scotland (T07/26 to W. F.).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Howie, Dr Jacqueline and Fuller, Dr Will
Authors: Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J., and Fuller, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Biological Chemistry
Publisher:American Society for Biochemistry and Molecular Biology, Inc.
ISSN:0021-9258
ISSN (Online):1083-351X
Published Online:25 August 2011

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