Regulation of the cardiac sodium pump

Fuller, W. , Tulloch, L.B., Shattock, M.J., Calaghan, S.C., Howie, J. and Wypijewski, K.J. (2013) Regulation of the cardiac sodium pump. Cellular and Molecular Life Sciences, 70(8), pp. 1357-1380. (doi:10.1007/s00018-012-1134-y) (PMID:22955490) (PMCID:PMC3607738)

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Abstract

In cardiac muscle, the sarcolemmal sodium/potassium ATPase is the principal quantitative means of active transport at the myocyte cell surface, and its activity is essential for maintaining the trans-sarcolemmal sodium gradient that drives ion exchange and transport processes that are critical for cardiac function. The 72-residue phosphoprotein phospholemman regulates the sodium pump in the heart: unphosphorylated phospholemman inhibits the pump, and phospholemman phosphorylation increases pump activity. Phospholemman is subject to a remarkable plethora of post-translational modifications for such a small protein: the combination of three phosphorylation sites, two palmitoylation sites, and one glutathionylation site means that phospholemman integrates multiple signaling events to control the cardiac sodium pump. Since misregulation of cytosolic sodium contributes to contractile and metabolic dysfunction during cardiac failure, a complete understanding of the mechanisms that control the cardiac sodium pump is vital. This review explores our current understanding of these mechanisms.

Item Type:Articles
Additional Information:This work was supported by grants from the Medical Research Council (G0700903 to W.F.) and British Heart Foundation (RG/07/001 to M.J.S. and W.F. and PG/10/93/28650 to W.F. and S.C.C).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Howie, Dr Jacqueline and Fuller, Dr Will
Authors: Fuller, W., Tulloch, L.B., Shattock, M.J., Calaghan, S.C., Howie, J., and Wypijewski, K.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cellular and Molecular Life Sciences
Publisher:Springer
ISSN:1420-682X
ISSN (Online):1420-9071
Published Online:07 September 2012
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in Cellular and Molecular Life Sciences 70:1357-1380
Publisher Policy:Reproduced under a Creative Commons License

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