Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. and Fuller, W. (2013) A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump. Journal of Biological Chemistry, 288(19), pp. 13808-13820. (doi: 10.1074/jbc.M113.460956) (PMID:23532852) (PMCID:PMC3650417)
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Abstract
Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues. Results: In cardiac muscle, a subpopulation of phospholemman with a unique phosphorylation signature associates with other phospholemman molecules but not with the pump. Conclusion: Phospholemman oligomers exist in cardiac muscle. Significance: Much like phospholamban regulation of SERCA, phospholemman exists as both a sodium pump inhibiting monomer and an unassociated oligomer.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Howie, Dr Jacqueline and Fuller, Professor Will |
Authors: | Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C., and Fuller, W. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Journal of Biological Chemistry |
Publisher: | American Society for Biochemistry and Molecular Biology |
ISSN: | 0021-9258 |
ISSN (Online): | 1083-351X |
Published Online: | 26 March 2013 |
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