A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump

Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. and Fuller, W. (2013) A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump. Journal of Biological Chemistry, 288(19), pp. 13808-13820. (doi:10.1074/jbc.M113.460956) (PMID:23532852) (PMCID:PMC3650417)

Full text not currently available from Enlighten.

Abstract

Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues. Results: In cardiac muscle, a subpopulation of phospholemman with a unique phosphorylation signature associates with other phospholemman molecules but not with the pump. Conclusion: Phospholemman oligomers exist in cardiac muscle. Significance: Much like phospholamban regulation of SERCA, phospholemman exists as both a sodium pump inhibiting monomer and an unassociated oligomer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Howie, Dr Jacqueline and Fuller, Dr Will
Authors: Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C., and Fuller, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Biological Chemistry
Publisher:American Society for Biochemistry and Molecular Biology
ISSN:0021-9258
ISSN (Online):1083-351X
Published Online:26 March 2013

University Staff: Request a correction | Enlighten Editors: Update this record