ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis

Perrella, G., Davidson, M. L.H., O'Donnell, L. , Nastase, A.-M., Herzyk, P. , Breton, G., Pruneda-Paz, J. L., Kay, S. A., Chory, J. and Kaiserli, E. (2018) ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 115(19), E4503-E4511. (doi: 10.1073/pnas.1718099115) (PMID:29686058) (PMCID:PMC5948964)

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Abstract

Integration of environmental signals and interactions among photoreceptors and transcriptional regulators is key in shaping plant development. TANDEM ZINC-FINGER PLUS3 (TZP) is an integrator of light and photoperiodic signaling that promotes flowering in Arabidopsis thaliana. Here we elucidate the molecular role of TZP as a positive regulator of hypocotyl elongation. We identify an interacting partner for TZP, the transcription factor ZINC-FINGER HOMEODOMAIN 10 (ZFHD10), and characterize its function in coregulating the expression of blue-light–dependent transcriptional regulators and growth-promoting genes. By employing a genome-wide approach, we reveal that ZFHD10 and TZP coassociate with promoter targets enriched in light-regulated elements. Furthermore, using a targeted approach, we show that ZFHD10 recruits TZP to the promoters of key coregulated genes. Our findings not only unveil the mechanism of TZP action in promoting hypocotyl elongation at the transcriptional level but also assign a function to an uncharacterized member of the ZFHD transcription factor family in promoting plant growth.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:O'Donnell, Miss Liz and Nastase, Ms Ana-Maria and Kaiserli, Dr Eirini and Herzyk, Dr Pawel and Perrella, Dr Giorgio
Authors: Perrella, G., Davidson, M. L.H., O'Donnell, L., Nastase, A.-M., Herzyk, P., Breton, G., Pruneda-Paz, J. L., Kay, S. A., Chory, J., and Kaiserli, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Proceedings of the National Academy of Sciences of the United States of America
Publisher:National Academy of Sciences
ISSN:0027-8424
ISSN (Online):1091-6490
Published Online:23 April 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Proceedings of the National Academy of Sciences of the United States of America 115(19):E4503-E4511
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
682711Transcriptional regulation of plant growth in nuclear microdomainsEirini KaiserliBiotechnology and Biological Sciences Research Council (BBSRC)BB/M023079/1RI MOLECULAR CELL & SYSTEMS BIOLOGY