Novel regulation of cardiac Na pump via phospholemman

Pavlovic, D., Fuller, W. and Shattock, M. J. (2013) Novel regulation of cardiac Na pump via phospholemman. Journal of Molecular and Cellular Cardiology, 61, pp. 83-93. (doi:10.1016/j.yjmcc.2013.05.002) (PMID:23672825)

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Abstract

As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it establishes is essential for normal electrical excitability, numerous coupled-transport processes and, as the driving force for Na/Ca exchange, thus setting cardiac Ca load and contractility. As Na influx varies with electrical excitation, heart rate and pathology, the dynamic regulation of Na efflux is essential. It is now widely recognized that phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation. Phospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. This review summarizes our current understanding of the multiple regulatory. This article is part of a Special Issue entitled “Na+ Regulation in Cardiac Myocytes”.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fuller, Dr Will
Authors: Pavlovic, D., Fuller, W., and Shattock, M. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Molecular and Cellular Cardiology
Publisher:Elsevier
ISSN:0022-2828
ISSN (Online):1095-8584
Published Online:12 May 2013
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Journal of Molecular and Cellular Cardiology 61:83-93
Publisher Policy:Reproduced under a Creative Commons License

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