Novel regulation of cardiac Na pump via phospholemman

Pavlovic, D., Fuller, W. and Shattock, M. J. (2013) Novel regulation of cardiac Na pump via phospholemman. Journal of Molecular and Cellular Cardiology, 61, pp. 83-93. (doi: 10.1016/j.yjmcc.2013.05.002) (PMID:23672825)

Abstract

As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it establishes is essential for normal electrical excitability, numerous coupled-transport processes and, as the driving force for Na/Ca exchange, thus setting cardiac Ca load and contractility. As Na influx varies with electrical excitation, heart rate and pathology, the dynamic regulation of Na efflux is essential. It is now widely recognized that phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation. Phospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. This review summarizes our current understanding of the multiple regulatory. This article is part of a Special Issue entitled “Na+ Regulation in Cardiac Myocytes”.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Fuller, Professor Will
• Authors: Pavlovic, D., Fuller, W., and Shattock, M. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Journal of Molecular and Cellular Cardiology
• Publisher: Elsevier
• ISSN: 0022-2828
• ISSN (Online): 1095-8584
• Published Online: 12 May 2013
• Copyright Holders: Copyright © 2013 The Authors
• First Published: First published in Journal of Molecular and Cellular Cardiology 61:83-93
• Publisher Policy: Reproduced under a Creative Commons License