Enlighten
Research publications by members of the University of Glasgow
home > services > Enlighten

Analysis of the autoimmune response in lupus mice: the behaviour and lifespan of anti-DNA-secreting B-cell clones

Stott, D.I., Brighouse, G., Gyotoku, Y., and Lambert, P. (1990) Analysis of the autoimmune response in lupus mice: the behaviour and lifespan of anti-DNA-secreting B-cell clones. Autoimmunity, 8 (2). pp. 159-168. ISSN 0891-6934 (doi:10.3109/08916939008995734)

Full text not currently available from Enlighten.

Abstract

We present the results of a study of the physical, haematological and serological features of the progress of the SLE-like syndrome in MRL/Mp-lpr/lpr and (NZB x NZW)Fl mice. As part of this study, we have analysed the IEF spectrotypes of anti-ssDNA antibodies in the sera of these mice and shown that the anti-ssDNA response is clonally restricted, as we have previously shown in a mouse chimaera model and in human SLE. Sequential qualitative and quantitative analysis of anti-ssDNA clonotypes has revealed that the lupus mouse anti-ssDNA clones are relatively short lived, having a lifespan of only 6 to 8 weeks, contrasting sharply with the much longer lifespan previously reported for a mouse anti-DNP-secreting clone and the exceptionally long lifespan of most anti-ssDNA-secreting clones of SLE patients. The implications of these observations for our understanding of the regulation of the autoimmune response are discussed.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stott, Prof David
Authors: Stott, D.I., Brighouse, G., Gyotoku, Y., and Lambert, P.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Autoimmunity
ISSN:0891-6934

University Staff: Request a correction | Enlighten Editors: Update this record