Functional assessment for acute stroke trials: properties, analysis, and application

Taylor-Rowan, M., Wilson, A., Dawson, J. and Quinn, T. J. (2018) Functional assessment for acute stroke trials: properties, analysis, and application. Frontiers in Neurology, 9, 191. (doi:10.3389/fneur.2018.00191)

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Abstract

A measure of treatment effect is needed to assess the utility of any novel intervention in acute stroke. For a potentially disabling condition such as stroke, outcomes of interest should include some measure of functional recovery. There are many functional outcome assessments that can be used after stroke. In this narrative review, we discuss exemplars of assessments that describe impairment, activity, participation, and quality of life. We will consider the psychometric properties of assessment scales in the context of stroke trials, focusing on validity, reliability, responsiveness, and feasibility. We will consider approaches to the analysis of functional outcome measures, including novel statistical approaches. Finally, we will discuss how advances in audiovisual and information technology could further improve outcome assessment in trials.

Item Type:Articles
Additional Information:MT-R is part funded by Chest Heart and Stroke Scotland; this work is part of the APPLE program of work funded by the Stroke Association and Chief Scientist Office Scotland. TQ is supported by a Stroke Association, Chief Scientist Office Senior Lectureship.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Taylor-Rowan, Martin and Dawson, Professor Jesse and Wilson, Dr Alastair and Quinn, Dr Terence
Authors: Taylor-Rowan, M., Wilson, A., Dawson, J., and Quinn, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Frontiers in Neurology
Publisher:Frontiers Media
ISSN:1664-2295
ISSN (Online):1664-2295
Copyright Holders:Copyright © 2018 Taylor-Rowan, Wilson, Dawson and Quinn
First Published:First published in Frontiers in Neurology 9: 191
Publisher Policy:Reproduced under a Creative Commons License

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