Rivers-Auty, J., Daniels, M. J.D., Colliver, I., Robertson, D. L. and Brough, D. (2018) Redefining the ancestral origins of the interleukin-1 superfamily. Nature Communications, 9, 1156. (doi: 10.1038/s41467-018-03362-1) (PMID:29559685) (PMCID:PMC5861070)
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Abstract
The interleukin-1 (IL-1) receptor and ligand families are components of the immune system. Knowledge of their evolutionary history is essential to understand their function. Using chromosomal anatomy and sequence similarity, we show that IL-1 receptor family members are related and nine members are likely formed from duplication and modification of a proto-IL-1R1 receptor. The IL-1 ligands have a different evolutionary history. The first proto-IL-1β gene coincided with proto-IL-1R1 and duplication events resulted in the majority of IL-1 ligand family members. However, large evolutionary distances are observed for IL-1α, IL-18 and IL-33 proteins. Further analysis show that IL-33 and IL-18 have poor sequence similarity and no chromosomal evidence of common ancestry with the IL-1β cluster and therefore should not be included in the IL-1 ligand ancestral family. IL-1α formed from the duplication of IL-1β, and moonlighting functions of pro-IL-1α acted as divergent selection pressures for the observed sequence dissimilarity.
| Item Type: | Articles |
|---|---|
| Additional Information: | J.R-A. was funded by the BBSRC (BB/P01061X/1). MJDD is funded by a MRC DTP studentship (MR/K501311/1). D.L.R. was partially supported by the MRC (MC_UU_12014/12). D.B. was partially funded by the Wellcome Trust (083482/Z/07/Z). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Robertson, Professor David |
| Authors: | Rivers-Auty, J., Daniels, M. J.D., Colliver, I., Robertson, D. L., and Brough, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Nature Communications |
| Publisher: | Nature Publishing Group |
| ISSN: | 2041-1723 |
| ISSN (Online): | 2041-1723 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Nature Communications 9: 1156 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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