Redefining the ancestral origins of the interleukin-1 superfamily

Rivers-Auty, J., Daniels, M. J.D., Colliver, I., Robertson, D. L. and Brough, D. (2018) Redefining the ancestral origins of the interleukin-1 superfamily. Nature Communications, 9, 1156. (doi:10.1038/s41467-018-03362-1) (PMID:29559685) (PMCID:PMC5861070)

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Abstract

The interleukin-1 (IL-1) receptor and ligand families are components of the immune system. Knowledge of their evolutionary history is essential to understand their function. Using chromosomal anatomy and sequence similarity, we show that IL-1 receptor family members are related and nine members are likely formed from duplication and modification of a proto-IL-1R1 receptor. The IL-1 ligands have a different evolutionary history. The first proto-IL-1β gene coincided with proto-IL-1R1 and duplication events resulted in the majority of IL-1 ligand family members. However, large evolutionary distances are observed for IL-1α, IL-18 and IL-33 proteins. Further analysis show that IL-33 and IL-18 have poor sequence similarity and no chromosomal evidence of common ancestry with the IL-1β cluster and therefore should not be included in the IL-1 ligand ancestral family. IL-1α formed from the duplication of IL-1β, and moonlighting functions of pro-IL-1α acted as divergent selection pressures for the observed sequence dissimilarity.

Item Type:Articles
Additional Information:J.R-A. was funded by the BBSRC (BB/P01061X/1). MJDD is funded by a MRC DTP studentship (MR/K501311/1). D.L.R. was partially supported by the MRC (MC_UU_12014/12). D.B. was partially funded by the Wellcome Trust (083482/Z/07/Z).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Robertson, Professor David
Authors: Rivers-Auty, J., Daniels, M. J.D., Colliver, I., Robertson, D. L., and Brough, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Communications
Publisher:Nature Publishing Group
ISSN:2041-1723
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Nature Communications 9: 1156
Publisher Policy:Reproduced under a Creative Commons License

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