NF-κB pathways in the development and progression of colorectal cancer

Patel, M., Horgan, P. G. , McMillan, D. C. and Edwards, J. (2018) NF-κB pathways in the development and progression of colorectal cancer. Translational Research, 197, pp. 43-56. (doi:10.1016/j.trsl.2018.02.002) (PMID:29550444)

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Abstract

Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes such as cell proliferation, apoptosis, angiogenesis, and metastasis. The role of NF-κB in CRC is complex, owed to the cross talk with other signaling pathways. Although there is sufficient evidence gained from cell lines and animal models that NF-κB is involved in cancer-related processes, because of a lack of studies in human tissue, the clinical evidence of its importance is limited in patients with CRC. This review summarizes evidence relating to how NF-κB is involved in the development and progression of CRC and comments on future work to be carried out.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Edwards, Professor Joanne and Horgan, Professor Paul and Patel, Dr Meera and McMillan, Professor Donald
Authors: Patel, M., Horgan, P. G., McMillan, D. C., and Edwards, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Translational Research
Publisher:Elsevier
ISSN:1931-5244
ISSN (Online):1878-1810
Published Online:01 March 2018
Copyright Holders:Copyright © 2018 Elsevier Inc.
First Published:First published in Translational Research 197: 43-56
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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