NF-κB pathways in the development and progression of colorectal cancer

Patel, M., Horgan, P. G. , McMillan, D. C. and Edwards, J. (2018) NF-κB pathways in the development and progression of colorectal cancer. Translational Research, 197, pp. 43-56. (doi: 10.1016/j.trsl.2018.02.002) (PMID:29550444)

Abstract

Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes such as cell proliferation, apoptosis, angiogenesis, and metastasis. The role of NF-κB in CRC is complex, owed to the cross talk with other signaling pathways. Although there is sufficient evidence gained from cell lines and animal models that NF-κB is involved in cancer-related processes, because of a lack of studies in human tissue, the clinical evidence of its importance is limited in patients with CRC. This review summarizes evidence relating to how NF-κB is involved in the development and progression of CRC and comments on future work to be carried out.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Horgan, Professor Paul and Edwards, Professor Joanne and Patel, Dr Meera and McMillan, Professor Donald
• Authors: Patel, M., Horgan, P. G., McMillan, D. C., and Edwards, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Translational Research
• Publisher: Elsevier
• ISSN: 1931-5244
• ISSN (Online): 1878-1810
• Published Online: 01 March 2018
• Copyright Holders: Copyright © 2018 Elsevier Inc.
• First Published: First published in Translational Research 197: 43-56
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher