Amino acids as mediators of metabolic cross talk between host and pathogen

Ren, W. et al. (2018) Amino acids as mediators of metabolic cross talk between host and pathogen. Frontiers in Immunology, 9, 319. (doi: 10.3389/fimmu.2018.00319) (PMID:29535717) (PMCID:PMC5835074)

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The interaction between host and pathogen decidedly shapes the outcome of an infection, thus understanding this interaction is critical to the treatment of a pathogen-induced infection. Although research in this area of cell biology has yielded surprising findings regarding interactions between host and pathogen, understanding of the metabolic cross talk between host and pathogen is limited. At the site of infection, host and pathogen share similar or identical nutritional substrates and generate common metabolic products, thus metabolic cross talk between host and pathogen could profoundly affect the pathogenesis of an infection. In this review, we present results of a recent discovery of a metabolic interaction between host and pathogen from an amino acid (AA) metabolism-centric point of view. The host depends on AA metabolism to support defensive responses against pathogens, while the pathogens modulate AA metabolism for its own advantage. Some AA, such as arginine, asparagine, and tryptophan, are central points of competition between the host and pathogen. Thus, a better understanding of AA-mediated metabolic cross talk between host and pathogen will provide insight into fruitful therapeutic approaches to manipulate and prevent progression of an infection.

Item Type:Articles
Additional Information:This study was supported by the National Key R & D Program (2016YFD0501201), the National Natural Science Foundation of China (31330075, 31372326, 31110103909, 31272463), Key  Programs  of  frontier scientific research of the Chinese Academy of Sciences (QYZDY-SSW-SMC008), and the Priority Academic Program of Development Jiangsu High Education Institution.
Keywords:Amino acids, arginine, asparagine, infection, metabolism.
Glasgow Author(s) Enlighten ID:Rajendran, Dr Ranjith
Authors: Ren, W., Rajendran, R., Zhao, Y., Tan, B., Wu, G., Bazer, F. W., Zhu, G., Peng, Y., Huang, X., Deng, J., and Yin, Y.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Frontiers in Immunology
ISSN (Online):1664-3224
Copyright Holders:Copyright © 2018 Ren, Rajendran, Zhao, Tan, Wu, Bazer, Zhu, Peng, Huang, Deng and Yin
First Published:First published in Frontiers in Immunology 9: 319
Publisher Policy:Reproduced under a Creative Commons License

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