The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination

Gray, J. I., Westerhof, L. and Macleod, M. K.L. (2018) The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination. Immunology, 154(4), pp. 574-581. (doi: 10.1111/imm.12929) (PMID:29570776) (PMCID:PMC6050220)

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Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses. Vaccines must, therefore, activate CD4 T cells if they are to generate protective immunity. For many diseases, we do not have effective vaccines. These include HIV, tuberculosis and malaria, which are responsible for many millions of deaths each year across the globe. CD4 T cells play many different roles during the immune response coordinating the actions of many other cells. In order to harness the diverse protective effects of memory CD4 T cells we need to understand how memory CD4 T cells are generated and how they protect the host. Here we review recent findings on the location of different subsets of memory CD4 T cells that are found in peripheral tissues (tissue resident memory T cells) and in the circulation (central and effector memory T cells). We discuss the generation of these cells and the evidence that demonstrates how they provide immune protection in animal and human challenge models.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Westerhof, Lotus and Macleod, Dr Megan and Gray, Joshua
Authors: Gray, J. I., Westerhof, L., and Macleod, M. K.L.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Immunology
ISSN (Online):1365-2567
Published Online:23 March 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Immunology 154(4):574-581
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
580941MRC Doctoral Training Grant 2011-2015Mary Beth KneafseyMedical Research Council (MRC)MR/J50032X/1VPO VICE PRINCIPAL RESEARCH & ENTERPRISE