Morrison, S. D. , Liskamp, R. M.J. and Prunet, J. (2018) Tailoring polyethers for efficient post-polymerization functionalization by cross metathesis. Organic Letters, 20(8), pp. 2253-2256. (doi: 10.1021/acs.orglett.8b00595) (PMID:29600865)
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Abstract
Olefin cross metathesis is reported for the first time to attach small molecules to a range of novel polyethers with a poly(ethylene glycol) backbone and pendent alkene groups, allowing for a loading of up to one compound per monomer unit. These polymers are tailored to prevent the occurrence of self metathesis (reaction of the polymer with itself) by varying the substitution on the pendent alkenes, thus steering their reactivity toward olefin cross metathesis. Efficient functionalization has been observed for a range of coupling partners as a proof of concept for the use of olefin metathesis to graft small and larger molecules to polyethers for drug delivery. This approach also paves the way for the use of olefin cross metathesis as an efficient method to functionalize a wide variety of polymers with pendent olefin groups.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert and Morrison, Mr Stephen and Prunet, Dr Joelle |
| Authors: | Morrison, S. D., Liskamp, R. M.J., and Prunet, J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Organic Letters |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7060 |
| ISSN (Online): | 1523-7052 |
| Published Online: | 30 March 2018 |
| Copyright Holders: | Copyright © 2018 American Chemical Society |
| First Published: | First published in Organic Letters 20(8): 2253-2256 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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