Rodrigues, C. M.C., Lucidarme, J., Borrow, R., Smith, A. , Cameron, J. C., Moxon, E. R. and Maiden, M. C.J. (2018) Genomic surveillance of 4CMenB vaccine antigenic variants among disease-causing Neisseria meningitidis isolates, United Kingdom, 2010–2016. Emerging Infectious Diseases, 24(4), pp. 673-682. (doi: 10.3201/eid2404.171480) (PMID:29553330) (PMCID:PMC5875271)
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Abstract
In September 2015, 4CMenB meningococcal vaccine was introduced into the United Kingdom infant immunization program without phase 3 trial information. Understanding the effect of this program requires enhanced surveillance of invasive meningococcal disease (IMD) Neisseria meningitidis isolates and comparison with prevaccination isolates. Bexsero Antigen Sequence Types (BASTs) were used to analyze whole-genome sequences of 3,073 prevaccine IMD N. meningitidis isolates obtained during 2010−2016. Isolates exhibited 803 BASTs among 31 clonal complexes. Frequencies of antigen peptide variants were factor H binding protein 1, 13.4%; Neisserial heparin-binding antigen 2, 13.8%; Neisseria adhesin A 8, 0.8%; and Porin A-VR2:P1.4,10.9%. In 2015−16, serogroup B isolates showed the highest proportion (35.7%) of exact matches to >1 Bexsero components. Serogroup W isolates showed the highest proportion (93.9%) of putatively cross-reactive variants of Bexsero antigens. Results highlighted the likely role of cross-reactive antigens. BAST surveillance of meningococcal whole-genome sequence data is rapid, scalable, and portable and enables international comparisons of isolates.
| Item Type: | Articles |
|---|---|
| Additional Information: | This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Smith, Professor Andrew |
| Authors: | Rodrigues, C. M.C., Lucidarme, J., Borrow, R., Smith, A., Cameron, J. C., Moxon, E. R., and Maiden, M. C.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
| Journal Name: | Emerging Infectious Diseases |
| Publisher: | Centers for Disease Control and Prevention |
| ISSN: | 1080-6040 |
| ISSN (Online): | 1080-6059 |
| Published Online: | 19 March 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Emerging Infectious Diseases 24(4): 673-682 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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