Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers

Hewett, J., Nadeau, V., Ferguson, J., Moseley, H., Ibbotson, S., Brancaleon, L., Birkin, D., Sibbett, W. and Padgett, M. (2001) Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers. Proceedings of the SPIE: The International Society for Optical Engineering, 4248, 68 -75. (doi:10.1117/12.424437)

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Publisher's URL: http://dx.doi.org/10.1117/12.424437

Abstract

We present a simple fluorescence imaging system for use in the demarcation and monitoring of skin cancers. The imaging system simultaneously acquires four spectrally specific images at 635, 600, 540 and 400 nm. The incorporation of an image intensifier, coupled with high speed image processing gives video update rates. The integrated light source is based on low cost fluorescent bulbs, shaped to fit around the lens and phosphor coated to give a peak emission near 400 nm, matched to the absorption maximum of PpIX. We apply this system to monitoring the fluorescence of the PpIX photosensitizer before during and after ALA based PDT.

Item Type:Articles
Additional Information:Presented at the 10th SPIE Conference, Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy, 20 January 2001, San Jose, CA, USA.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Padgett, Professor Miles
Authors: Hewett, J., Nadeau, V., Ferguson, J., Moseley, H., Ibbotson, S., Brancaleon, L., Birkin, D., Sibbett, W., and Padgett, M.
Subjects:Q Science > QC Physics
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Science and Engineering > School of Physics and Astronomy
Journal Name:Proceedings of the SPIE: The International Society for Optical Engineering
Publisher:SPIE - The International Society for Optical Engineering
ISSN:0277-786X

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