Clinical burden of modified Glasgow Prognostic Scale in colorectal cancer

Okugawa, Y. et al. (2018) Clinical burden of modified Glasgow Prognostic Scale in colorectal cancer. Anticancer Research, 38(3), pp. 1599-1610. (doi:10.21873/anticanres.12390) (PMID:29491091)

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Abstract

This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition.

Item Type:Articles
Keywords:Colorectal cancer, eicosapentaenoic acid, fish oil, modified Glasgow prognostic scale, nutrition, prognosis.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMillan, Professor Donald
Authors: Okugawa, Y., Shirai, Y., Toiyama, Y., Saigusa, S., Hishida, A., Yokoe, T., Tanaka, K., Tanaka, M., Yasuda, H., Fujikawa, H., Hiro, J., Kobayashi, M., Araki, T., Inoue, Y., McMillan, D. C., Kusunoki, M., and Miki, C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Anticancer Research
Publisher:International Institute of Anticancer Research
ISSN:0250-7005
ISSN (Online):1791-7530
Copyright Holders:Copyright © 2018 The Authors

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