Cloning and chromosomal localization of human Cdc42-binding protein kinase β

Moncrieff, C. L., Bailey, M. E.S. , Morrison, N. and Johnson, K. J. (1999) Cloning and chromosomal localization of human Cdc42-binding protein kinase β. Genomics, 57(2), pp. 297-300. (doi: 10.1006/geno.1999.5769)

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The p21 GTPases, Rho and Cdc42, regulate numerous cellular functions by binding to members of a serine/threonine protein kinase subfamily. These functions include the remodeling of the cell cytoskeleton that is a feature of cell growth and differentiation. Two of these p21 GTPase-regulated kinases, the myotonic dystrophy protein kinase-related Cdc42-binding kinases (MRCKαand β), have been recently characterized in rat. Both of these proteins phosphorylate nonmuscle myosin light chain, a prerequisite for the activation of actin–myosin contractility. Here we report the cDNA cloning of the human homologue of MRCKβ, CDC42BPB, which was found by Northern blot analysis to be expressed in a wide range of tissues. The human CDC42BPB gene maps to cytogenetic band 14q32.3 by FISH analysis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Bailey, Dr Mark
Authors: Moncrieff, C. L., Bailey, M. E.S., Morrison, N., and Johnson, K. J.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Genomics
ISSN (Online):1089-8646

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