Ultrasound Facilitated Marking of Gastrointestinal Tissue With Fluorescent Material

Cox, B.F., Stewart, F., Huang, Z., Nathke, I.S. and Cochran, S. (2016) Ultrasound Facilitated Marking of Gastrointestinal Tissue With Fluorescent Material. In: 2016 IEEE International Ultrasonics Symposium, Tours, France, 18-21 Sept 2016, ISBN 9781467398978 (doi:10.1109/ULTSYM.2016.7728782)

Cox, B.F., Stewart, F., Huang, Z., Nathke, I.S. and Cochran, S. (2016) Ultrasound Facilitated Marking of Gastrointestinal Tissue With Fluorescent Material. In: 2016 IEEE International Ultrasonics Symposium, Tours, France, 18-21 Sept 2016, ISBN 9781467398978 (doi:10.1109/ULTSYM.2016.7728782)

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Abstract

The epithelial lining of the gastrointestinal (GI) mucosal layer is an effective barrier to the contents of the gut lumen. Selective channels and tight junctions prevent contamination of the sterile internal environment of the body. Conversely, the gut barrier also prevents desired agents from entering the GI tissue. This hinders marking of tissue for further clinical follow-up. Focused ultrasound (US) may provide a potential means of overcoming the gut barrier and allowing penetration of material beyond it which was explored in a series of tests. Experiments were carried out on 14 individual postmortem-obtained murine small bowel samples for a total of 23 sonication/control paired tests. A favourable result of 80% indicated that focused US can pass a nanoscale fluorescent agent through the gut barrier. Further work is required to elucidate where the agent resides, intercellular or intracellular, post-sonication.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cox, Dr Benjamin F and Cochran, Professor Alexander
Authors: Cox, B.F., Stewart, F., Huang, Z., Nathke, I.S., and Cochran, S.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
ISSN:1948-5727
ISBN:9781467398978
Published Online:03 November 2016

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
615381Sonopill: minimally invasive gastrointestinal diagnosis and therapyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/1ENG - ENGINEERING ELECTRONICS & NANO ENG
748241Sonopill: minimally invasive gastrointestinal diagnosis and therapyAlexander CochranEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/2ENG - ENGINEERING SYSTEMS POWER & ENERGY