Iron–sulfur clusters: from metals through mitochondria biogenesis to disease

Cardenas-Rodriguez, M., Chatzi, A. and Tokatlidis, K. (2018) Iron–sulfur clusters: from metals through mitochondria biogenesis to disease. Journal of Biological Inorganic Chemistry, 23(4), pp. 509-520. (doi: 10.1007/s00775-018-1548-6) (PMID:29511832) (PMCID:PMC6006200)

Abstract

Iron–sulfur clusters are ubiquitous inorganic co-factors that contribute to a wide range of cell pathways including the maintenance of DNA integrity, regulation of gene expression and protein translation, energy production, and antiviral response. Specifically, the iron–sulfur cluster biogenesis pathways include several proteins dedicated to the maturation of apoproteins in different cell compartments. Given the complexity of the biogenesis process itself, the iron–sulfur research area constitutes a very challenging and interesting field with still many unaddressed questions. Mutations or malfunctions affecting the iron–sulfur biogenesis machinery have been linked with an increasing amount of disorders such as Friedreich’s ataxia and various cardiomyopathies. This review aims to recap the recent discoveries both in the yeast and human iron–sulfur cluster arena, covering recent discoveries from chemistry to disease.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cardenas Rodriguez, Mr Mauricio and Tokatlidis, Professor Kostas and Chatzi, Ms Afroditi
• Authors: Cardenas-Rodriguez, M., Chatzi, A., and Tokatlidis, K.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Journal of Biological Inorganic Chemistry
• Publisher: Springer
• ISSN: 0949-8257
• ISSN (Online): 1432-1327
• Published Online: 06 March 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Journal of Biological Inorganic Chemistry 23(4): 509-520
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
74346	1	Characterizing the mitochondrial import and assembly pathway of the malaria parasites	Konstantinos Tokatlidis	Wellcome Trust (WELLCOTR)	202308/Z/16/Z	RI MOLECULAR CELL & SYSTEMS BIOLOGY
62493	1	Oxidative Folding and Redox Signalling in the Mitochondria Intermembrane Space.	Konstantinos Tokatlidis	The Royal Society (ROYSOC)	WM120111	RI MOLECULAR CELL & SYSTEMS BIOLOGY