Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

Abánades Lázaro, I., Abánades Lázaro, S. and Forgan, R. S. (2018) Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles. Chemical Communications, 54(22), pp. 2792-2795. (doi:10.1039/C7CC09739E) (PMID:29485148)

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Abstract

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Abanades, Isabel and Forgan, Dr Ross
Authors: Abánades Lázaro, I., Abánades Lázaro, S., and Forgan, R. S.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:22 February 2018
Copyright Holders:Copyright © 2018 Royal Society of Chemistry
First Published:First published in Chemical Communications 52(22): 2792-2795
Publisher Policy:Reproduced under a Creative Commons License

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