ILDR2 is a novel B7-like protein that negatively regulates T cell responses

Hecht, I. et al. (2018) ILDR2 is a novel B7-like protein that negatively regulates T cell responses. Journal of Immunology, 200(6), pp. 2025-2037. (doi:10.4049/jimmunol.1700325) (PMID:29431694)

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Abstract

The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies for human diseases. We identified Ig-like domain-containing receptor (ILDR)2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Kurowska-Stolarska, Dr Mariola and Gilmour, Miss Ashley and Tange, Miss Clare and McIntyre, Dr Donna and Elmesmari, Dr Aziza
Authors: Hecht, I., Toporik, A., Podojil, J. R., Vaknin, I., Cojocaru, G., Oren, A., Aizman, E., Liang, S. C., Leung, L., Dicken, Y., Novik, A., Marbach-Bar, N., Elmesmari, A., Tange, C., Gilmour, A., McIntyre, D., Kurowska-Stolarska, M., McNamee, K., Leitner, J., Greenwald, S., Dassa, L., Levine, Z., Steinberger, P., Williams, R. O., Miller, S. D., McInnes, I. B., Neria, E., and Rotman, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Immunology
Publisher:American Association of Immunologists
ISSN:0022-1767
ISSN (Online):1550-6606
Published Online:05 February 2018

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