Transient disruption of M1 during response planning impairs subsequent offline consolidation

Cohen, N. R., Cross, E. S. , Wymbs, N. F. and Grafton, S. T. (2009) Transient disruption of M1 during response planning impairs subsequent offline consolidation. Experimental Brain Research, 196(2), pp. 303-309. (doi: 10.1007/s00221-009-1838-x) (PMID:19462166) (PMCID:PMC2693775)

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Abstract

Transcranial magnetic stimulation (TMS) was used to probe the involvement of the left primary motor cortex (M1) in the consolidation of a sequencing skill. In particular we asked: (1) if M1 is involved in consolidation of planning processes prior to response execution (2) whether movement preparation and movement execution can undergo consolidation independently and (3) whether sequence consolidation can occur in a stimulus specific manner. TMS was applied to left M1 while subjects prepared left hand sequential finger responses for three different movement sequences, presented in an interleaved fashion. Subjects also trained on three control sequences, where no TMS was applied. Disruption of subsequent consolidation was observed, but only for sequences where subjects had been exposed to TMS during training. Further, reduced consolidation was only observed for movement preparation, not movement execution. We conclude that left M1 is causally involved in the consolidation of effective response planning for left hand movements prior to response execution, and mediates consolidation in a sequence specific manner. These results provide important new insights into the role of M1 in sequential memory consolidation and sequence response planning.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cross, Professor Emily
Authors: Cohen, N. R., Cross, E. S., Wymbs, N. F., and Grafton, S. T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Experimental Brain Research
Publisher:Springer
ISSN:0014-4819
ISSN (Online):1432-1106
Published Online:22 May 2009

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