Vector species-specific association between natural Wolbachia infections and avian malaria in black fly populations

Woodford, L., Bianco, G., Ivanova, Y., Dale, M., Elmer, K. , Rae, F., Larcombe, S. D., Helm, B., Ferguson, H. M. and Baldini, F. (2018) Vector species-specific association between natural Wolbachia infections and avian malaria in black fly populations. Scientific Reports, 8, 4188. (doi:10.1038/s41598-018-22550-z) (PMID:29520067)

[img]
Preview
Text
157699.pdf - Published Version
Available under License Creative Commons Attribution.

2MB

Abstract

Artificial infection of mosquitoes with the endosymbiont bacteria Wolbachia can interfere with malaria parasite development. Therefore, the release of Wolbachia-infected mosquitoes has been proposed as a malaria control strategy. However, Wolbachia effects on vector competence are only partly understood, as indicated by inconsistent effects on malaria infection reported under laboratory conditions. Studies of naturally-occurring Wolbachia infections in wild vector populations could be useful to identify the ecological and evolutionary conditions under which these endosymbionts can block malaria transmission. Here we demonstrate the occurrence of natural Wolbachia infections in three species of black fly (genus Simulium), which is a main vector of the avian malaria parasite Leucocytozoon. Prevalence of Leucocytozoon was high (25%), but the nature and magnitude of its association with Wolbachia differed between black fly species. Wolbachia infection was positively associated with avian malaria infection in S. cryophilum, negatively associated in S. aureum, and unrelated in S. vernum. These differences suggest that Wolbachia interacts with the parasite in a vector host species-specific manner. This provides a useful model system for further study of how Wolbachia influences vector competence. Such knowledge, including the possibility of undesirable positive association, is required to guide endosymbiont based control methods.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baldini, Dr Francesco and Rae, Miss Fiona and Elmer, Dr Kathryn and Ferguson, Professor Heather and Helm, Dr Barbara and Larcombe, Dr Stephen
Authors: Woodford, L., Bianco, G., Ivanova, Y., Dale, M., Elmer, K., Rae, F., Larcombe, S. D., Helm, B., Ferguson, H. M., and Baldini, F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Published Online:08 March 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Scientific Reports 8:4188
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record