Penicillium marneffei infection presenting as an immune reconstitution inflammatory syndrome in an HIV patient

Ho, A. , Shankland, G.S. and Seaton, R.A. (2010) Penicillium marneffei infection presenting as an immune reconstitution inflammatory syndrome in an HIV patient. International Journal of STD and AIDS, 21(11), pp. 780-782. (doi:10.1258/ijsa.2010.010164) (PMID:21187363)

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Abstract

We describe a case of Penicillium marneffei infection acquired in Thailand, manifesting as an immune reconstitution inflammatory syndrome (IRIS) in a Caucasian man with advanced HIV-related immunosuppression (CD4 72 cells/mm3). Initial presentation was consistent with Pneumocystis jirovecii pneumonia, and empirical co-trimoxazole resulted in clinical improvement. One month after initiating antiretroviral therapy (ART), an enlarging scaly lesion on his forehead and erythematous nodules on his face, trunk and limbs developed. P. marneffei was isolated from a skin aspirate. Response to antifungal therapy was complicated by drug interactions but cure was complete after four months of treatment. Few cases of IRIS associated with P. marneffei have been reported.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ho, Dr Antonia
Authors: Ho, A., Shankland, G.S., and Seaton, R.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of STD and AIDS
Publisher:SAGE Publications
ISSN:0956-4624
ISSN (Online):1758-1052
Published Online:01 November 2010

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