Calculation of air supply rates and concentrations of airborne contamination in non-UDAF cleanrooms

Whyte, W. , Eaton, T., Whyte, W.M., Lenegan, N., Ward, S. and Agricola, K. (2017) Calculation of air supply rates and concentrations of airborne contamination in non-UDAF cleanrooms. European Journal of Parenteral and Pharmaceutical Sciences, 22(4), pp. 126-138.

Abstract

This article reviews a series of scientific articles written by the authors, where the following topics were investigated in relation to non-unidirectional airflow cleanrooms. (1) The air supply rate required to obtain a specified concentration of airborne contamination. (2) The calculation of concentrations of airborne contaminants in different ventilation and dispersion of contamination situations. (3) The decay of airborne contamination (a) during the ‘clean up’ test described in Annex 1 of the EU Guidelines to Good Manufacturing Practice (2008); (b) during the recovery rate test described in Annex B12 of ISO 14644-3 (2005); (c) associated with clean areas, such as airlocks, to reduce airborne contamination before a door into a cleanroom is opened. Worked examples are provided to demonstrate the calculation methods to provide solutions to the above topics.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Whyte, Dr William
• Authors: Whyte, W., Eaton, T., Whyte, W.M., Lenegan, N., Ward, S., and Agricola, K.
• College/School: College of Science and Engineering > School of Engineering
• Journal Name: European Journal of Parenteral and Pharmaceutical Sciences
• Publisher: Euromed Communications
• ISSN: 0964-4679
• Copyright Holders: Copyright © 2017 Euromed Communications
• First Published: First published in European Journal of Parenteral and Pharmaceutical Sciences 22(4):126-138
• Publisher Policy: Reproduced with the permission of the publisher