Girt, G. C., Mahindra, A., Al Jabri, Z. J.H., De Ste Croix, M., Oggioni, M. R. and Jamieson, A. G. (2018) Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus. Chemical Communications, 54(22), pp. 2767-2770. (doi: 10.1039/C7CC06093A) (PMID:29484340)
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Abstract
A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1–6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL−1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jamieson, Professor Andrew and Mahindra, Dr Amit |
Authors: | Girt, G. C., Mahindra, A., Al Jabri, Z. J.H., De Ste Croix, M., Oggioni, M. R., and Jamieson, A. G. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Chemical Communications |
Publisher: | Royal Society of Chemistry |
ISSN: | 1359-7345 |
ISSN (Online): | 1364-548X |
Published Online: | 27 February 2018 |
Copyright Holders: | Copyright © 2018 Royal Society of Chemistry |
First Published: | First published in Chemical Communications 54(22): 2767-2770 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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