Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus

Girt, G. C., Mahindra, A., Al Jabri, Z. J.H., De Ste Croix, M., Oggioni, M. R. and Jamieson, A. G. (2018) Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus. Chemical Communications, 54(22), pp. 2767-2770. (doi: 10.1039/C7CC06093A) (PMID:29484340)

[img]
Preview
Text
157529.pdf - Accepted Version

1MB

Abstract

A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1–6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL−1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mahindra, Dr Amit and Jamieson, Professor Andrew
Authors: Girt, G. C., Mahindra, A., Al Jabri, Z. J.H., De Ste Croix, M., Oggioni, M. R., and Jamieson, A. G.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:27 February 2018
Copyright Holders:Copyright © 2018 Royal Society of Chemistry
First Published:First published in Chemical Communications 54(22): 2767-2770
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record