Characterization of the Gamboa virus serogroup (Orthobunyavirus genus, Peribunyaviridae family)

Chiang, J. O. et al. (2018) Characterization of the Gamboa virus serogroup (Orthobunyavirus genus, Peribunyaviridae family). American Journal of Tropical Medicine and Hygiene, 98(5), pp. 1502-1511. (doi: 10.4269/ajtmh.17-0810) (PMID:29436340)

Abstract

Comprehensive comparative phylogenetic analyses were performed on 17 Gamboa serogroup viruses (GAMSVs) from distinct geographic regions in the Americas and other representative members of the genus Orthobunyavirus (Peribunyaviridae), based on small (S), medium (M), and large (L) open reading frame full-length and partial sequences. Genome characterization showed that the GAMSVs divide into four clades or genotypes. The GAMSVs have a genetic organization similar to other orthobunyaviruses, except that they have a larger NSm protein than other orthobunyaviruses. A serosurvey for Gamboa virus antibodies was performed in plasma from birds, other wild animals, and humans living around the Tucuruí hydroelectric dam in Pará state, northern Brazil, a known focus of GAMSV activity. Newborn chicks (Gallus gallus domesticus) were experimentally infected with a GAMSV, and the pathogenesis is described. Histopathological changes were primarily in the lungs and liver. Also, a review of the ecology of the GAMSVs in the Americas is included. In sum, this study presents the genomic and evolutionary characterization of the Gamboa group and the potential model of pathogenesis, which would be helpful for diagnostic purposes, epidemiology, and immunopathogenesis studies.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Souza, Mr William
• Authors: Chiang, J. O., Patroca da Silva, S., Marciel de Souza, W., Dorta de Silva, P. H., Vasilakis, N., Watanabe de Sousa, A., Tesh, R. B., Paes de Andrade Travassos da Rosa, A., Dutary, B., Mesquita de Freitas, N., Guzmán, H., Teixeira Nunes, M. R., Rodrigues, S. G., Acrani, G. O., Simões Quaresma, J. A., and Fernando da Costa Vasconcelos, P.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: American Journal of Tropical Medicine and Hygiene
• Publisher: American Society of Tropical Medicine and Hygiene
• ISSN: 0002-9637
• ISSN (Online): 1476-1645
• Published Online: 12 February 2018
• Copyright Holders: Copyright © 2018 The American Society of Tropical Medicine and Hygiene
• First Published: First published in American Journal of Tropical Medicine and Hygiene 98(5):1502-1511
• Publisher Policy: Reproduced in accordance with the publisher copyright policy