Nanoimprinting of biomedical polymers reduces candidal physical adhesion

Alalwan, H., Nile, C. J. , Rajendran, R., McKerlie, R. , Reynolds, P. , Gadegaard, N. and Ramage, G. (2018) Nanoimprinting of biomedical polymers reduces candidal physical adhesion. Nanomedicine: Nanotechnology, Biology and Medicine, 14(3), pp. 1045-1049. (doi:10.1016/j.nano.2018.01.011) (PMID:29408656)

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Abstract

Management of fungal biofilms represents a significant challenge to healthcare. As a preventive approach, minimising adhesion between indwelling medical devices and microorganisms would be an important step forward. This study investigated the anti-fouling capacity of engineered nanoscale topographies to the pathogenic yeast Candida albicans. Highly ordered arrays of nano-pit topographies were shown to significantly reduce the physical adherence capacity of C. albicans. This study shows a potential of nanoscale patterns to inhibit and prevent pathogenic biofilm formation on biomedical substrates.

Item Type:Articles
Keywords:Candida albicans, Nanotopography, adhesion, polycarbonate, polymethyl-methacrylate.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ramage, Professor Gordon and McKerlie, Mr Robert and Rajendran, Dr Ranjith and Nile, Dr Christopher and ALALWAN, HASANAIN KAHTAN ABDULKHALIK and Gadegaard, Professor Nikolaj and Reynolds, Dr Paul
Authors: Alalwan, H., Nile, C. J., Rajendran, R., McKerlie, R., Reynolds, P., Gadegaard, N., and Ramage, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Nanomedicine: Nanotechnology, Biology and Medicine
Publisher:Elsevier
ISSN:1549-9634
ISSN (Online):1549-9634
Published Online:02 February 2018

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