Visit-to-visit lipid variability: clinical significance, effects of lipid-lowering treatment, and (pharmaco)genetics

Smit, R. A. J., Jukema, J. W., Postmus, I., Ford, I. , Slagboom, P. E., Heijmans, B. T., Le Cessie, S. and Trompet, S. (2018) Visit-to-visit lipid variability: clinical significance, effects of lipid-lowering treatment, and (pharmaco)genetics. Journal of Clinical Lipidology, 12(2), 266-276.e3. (doi: 10.1016/j.jacl.2018.01.001) (PMID:29422286)

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Abstract

In recent years, visit-to-visit variability of serum lipids has been linked to both clinical outcomes and surrogate markers for vascular disease. In this article, we present an overview of the current evidence connecting this intraindividual variability to these outcome measures, discuss its interplay with lipid-lowering treatment, and describe the literature regarding genetic factors of possible interest. In addition, we undertook an explorative genome-wide association analysis on visit-to-visit variability of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, examining additive effects in 2530 participants from the placebo arm of the PROspective Study of Pravastatin in the Elderly at Risk trial. While we identified suggestive associations (P < 1 × 10−6) at 3 different loci (KIAA0391, amiloride-sensitive cation channel 1 neuronal [ACCN1], and Dickkopf WNT signaling pathway inhibitor 3 [DKK3]), previously published data from the genome-wide association study literature did not suggest plausible mechanistic pathways. Given the large degree of both clinical and methodological heterogeneity in the literature, additional research is needed to harmonize visit-to-visit variability parameters across studies and to definitively assess the possible role of (pharmaco)genetic factors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ford, Professor Ian
Authors: Smit, R. A. J., Jukema, J. W., Postmus, I., Ford, I., Slagboom, P. E., Heijmans, B. T., Le Cessie, S., and Trompet, S.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Journal of Clinical Lipidology
Publisher:Elsevier
ISSN:1933-2874
ISSN (Online):1876-4789
Published Online:11 January 2018
Copyright Holders:Copyright © 2018 Elsevier Inc.
First Published:First published in Journal of Clinical Lipidology 12(2): 266-276.e3
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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