Nanotechnology in Multimodal Theranostic Capsule Endoscopy

Cochran, S. , Button, T.W., Cox, B.F., Cumming, D.R.S. , Gourevich, D., Lay, H.S. , Mulvana, H., Nathke, I.S. and Stewart, F. (2017) Nanotechnology in Multimodal Theranostic Capsule Endoscopy. In: IEEE 17th International Conference on Nanotechnology (IEEE-NANO), Pittsburgh, PA, USA, 25-28 July 2017, pp. 434-435. ISBN 9781509030286 (doi:10.1109/NANO.2017.8117439)

157413.pdf - Accepted Version



Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

Item Type:Conference Proceedings
Glasgow Author(s) Enlighten ID:Mulvana, Dr Helen and Cumming, Professor David and Cochran, Professor Sandy and Lay, Dr Holly
Authors: Cochran, S., Button, T.W., Cox, B.F., Cumming, D.R.S., Gourevich, D., Lay, H.S., Mulvana, H., Nathke, I.S., and Stewart, F.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Copyright Holders:Copyright © 2017 IEEE
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
615381Sonopill: minimally invasive gastrointestinal diagnosis and therapyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/1ENG - ENGINEERING ELECTRONICS & NANO ENG