Hamdan, K.A., Tait, I.S., Nadeau, V., Padgett, M. , Carey, F. and Steele, R.J. (2003) Treatment of grade III anal intraepithelial neoplasia with photodynamic therapy - report of a case. Diseases of the Colon and Rectum, 46(11), 1555 -1559. (doi: 10.1007/s10350-004-6813-9)
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Publisher's URL: http://dx.doi.org/10.1007/s10350-004-6813-9
Abstract
PURPOSE: We report the use of photodynamic therapy to treat a 53-year-old female with Grade III anal intraepithelial neoplasia. METHODS: Topical 5-aminolevulinic acid cream was applied to the affected area five hours before light treatment. The distribution of 5-aminolevulinic acid-induced protoporphyrin IX was identified by its characteristic red fluorescence. The lesion was treated by illumination with a 630-nm red laser light that used a total energy of 125 J/cm(2) for approximately 17 minutes. RESULTS: Complete symptomatic relief was achieved after the first photodynamic therapy session, and macroscopic and microscopic ablation of dysplasia was achieved after a second session of photodynamic therapy. Healing was excellent, with no residual scarring or functional loss. CONCLUSION: Photodynamic therapy offers a simple, noninvasive method for treatment of anal intraepithelial neoplasia.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Padgett, Professor Miles |
Authors: | Hamdan, K.A., Tait, I.S., Nadeau, V., Padgett, M., Carey, F., and Steele, R.J. |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
College/School: | College of Science and Engineering > School of Physics and Astronomy |
Journal Name: | Diseases of the Colon and Rectum |
ISSN: | 0012-3706 |
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