Treatment of grade III anal intraepithelial neoplasia with photodynamic therapy - report of a case

Hamdan, K.A., Tait, I.S., Nadeau, V., Padgett, M. , Carey, F. and Steele, R.J. (2003) Treatment of grade III anal intraepithelial neoplasia with photodynamic therapy - report of a case. Diseases of the Colon and Rectum, 46(11), 1555 -1559. (doi:10.1007/s10350-004-6813-9)

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Publisher's URL: http://dx.doi.org/10.1007/s10350-004-6813-9

Abstract

PURPOSE: We report the use of photodynamic therapy to treat a 53-year-old female with Grade III anal intraepithelial neoplasia. METHODS: Topical 5-aminolevulinic acid cream was applied to the affected area five hours before light treatment. The distribution of 5-aminolevulinic acid-induced protoporphyrin IX was identified by its characteristic red fluorescence. The lesion was treated by illumination with a 630-nm red laser light that used a total energy of 125 J/cm(2) for approximately 17 minutes. RESULTS: Complete symptomatic relief was achieved after the first photodynamic therapy session, and macroscopic and microscopic ablation of dysplasia was achieved after a second session of photodynamic therapy. Healing was excellent, with no residual scarring or functional loss. CONCLUSION: Photodynamic therapy offers a simple, noninvasive method for treatment of anal intraepithelial neoplasia.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Padgett, Professor Miles
Authors: Hamdan, K.A., Tait, I.S., Nadeau, V., Padgett, M., Carey, F., and Steele, R.J.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Science and Engineering > School of Physics and Astronomy
Journal Name:Diseases of the Colon and Rectum
ISSN:0012-3706

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