The internal dynamic modes of charged self-assembled peptide fibrils

Carrick, L., Tassieri, M. , Waigh, T.A., Aggeli, A., Boden, N., Bell, C., Fisher, J., Ingham, E. and Evans, R.M.L. (2005) The internal dynamic modes of charged self-assembled peptide fibrils. Langmuir, 21(9), pp. 3733-3737. (doi:10.1021/la046802f) (PMID:15835929)

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Abstract

Photon correlation spectroscopy is used to study the internal dynamics of self-assembled charged peptide fibrils. Short neutral and charged polymeric aggregates have diffusive modes due to whole macromolecular motion. For long semiflexible fibrils the logarithm of the intermediate scattering function follows a q2t3/4 scaling at long times consistent with a Kratky-Porod free energy and preaveraged Oseen hydrodynamics. Persistence lengths on the order of micrometers are calculated for the peptide fibrils consistent with estimates from the liquid-crystalline phase behavior. Fibril diameters (5-35 nm) calculated from the initial decay of the correlation functions are in agreement with transmission electron microscopy measurements.

Item Type:Articles
Additional Information:We thank the EPSRC and the Royal Society for funding this research.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tassieri, Dr Manlio
Authors: Carrick, L., Tassieri, M., Waigh, T.A., Aggeli, A., Boden, N., Bell, C., Fisher, J., Ingham, E., and Evans, R.M.L.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Langmuir
Publisher:American Chemical Society
ISSN:0743-7463
ISSN (Online):1520-5827
Published Online:24 March 2005

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