Kitson, P. J., Marie, G., Francoia, J.-P., Zalesskiy, S. S., Sigerson, R. C., Mathieson, J. S. and Cronin, L. (2018) Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals. Science, 359(6373), pp. 314-319. (doi: 10.1126/science.aao3466) (PMID:29348235)
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Abstract
Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations. We demonstrate the approach for the γ-aminobutyric acid receptor agonist, (±)-baclofen, establishing a concept that paves the way for the local manufacture of drugs outside of specialist facilities.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mathieson, Dr Jennifer and Marie, Dr Guillaume and Zalesskiy, Dr Sergey and Sigerson, Mr Ralph and Francoia, Dr Jean-Patrick and Cronin, Professor Lee and Kitson, Dr Philip |
Authors: | Kitson, P. J., Marie, G., Francoia, J.-P., Zalesskiy, S. S., Sigerson, R. C., Mathieson, J. S., and Cronin, L. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Science |
Publisher: | American Association for the Advancement of Science |
ISSN: | 0036-8075 |
ISSN (Online): | 1095-9203 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Science 359(6373): 314-319 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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