Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals

Kitson, P. J., Marie, G., Francoia, J.-P., Zalesskiy, S. S., Sigerson, R. C., Mathieson, J. S. and Cronin, L. (2018) Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals. Science, 359(6373), pp. 314-319. (doi:10.1126/science.aao3466) (PMID:29348235)

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Abstract

Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations. We demonstrate the approach for the γ-aminobutyric acid receptor agonist, (±)-baclofen, establishing a concept that paves the way for the local manufacture of drugs outside of specialist facilities.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mathieson, Dr Jennifer and Marie, Dr Guillaume and Zalesskiy, Dr Sergey and Sigerson, Dr Ralph and Francoia, Dr Jean-Patrick and Cronin, Professor Leroy and Kitson, Dr Philip
Authors: Kitson, P. J., Marie, G., Francoia, J.-P., Zalesskiy, S. S., Sigerson, R. C., Mathieson, J. S., and Cronin, L.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Science
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
ISSN (Online):1095-9203
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Science 359(6373): 314-319
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
503291Molecular-Metal-Oxide-nanoelectronicS (M-MOS): Achieving the Molecular LimitLeroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/H024107/1CHEM - CHEMISTRY
577391Programmable Molecular Metal Oxides (PMMOs) - From Fundamentals to ApplicationLeroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/J015156/1CHEM - CHEMISTRY
605821The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - ENGINEERING ELECTRONICS & NANO ENG
633821A Digital DNA Nano Writer (DNA NanoFab)Leroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/L015668/1CHEM - CHEMISTRY
646611Programmable 'Digital' Synthesis for Discovery and Scale-up of Molecules, Clusters and NanomaterialsLeroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/L023652/1CHEM - CHEMISTRY
685741SMARTPOM: Artificial-Intelligence Driven Discovery and Synthesis of Polyoxometalate ClustersLeroy CroninEuropean Research Council (ERC)670467CHEM - CHEMISTRY