Extended-spectrum beta-lactamases-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru

Benavides, J.A., Shiva, C., Virhuez, M., Tello, C., Appelgren, A., Vendrell, J., Solassol, J., Godreuil, S. and Streicker, D.G. (2018) Extended-spectrum beta-lactamases-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru. Zoonoses and Public Health, 65(4), pp. 373-463. (doi:10.1111/zph.12456) (PMID:29575785)

[img]
Preview
Text
156404.pdf - Published Version
Available under License Creative Commons Attribution.

414kB

Abstract

Antibiotic resistance mediated by bacterial production of extended‐spectrum beta‐lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital‐acquired; however, infections acquired outside of hospital settings have raised concerns over the role of livestock and wildlife in the zoonotic spread of ESBL‐producing bacteria. Only limited data are available on the circulation of ESBL‐producing bacteria in animals. Here, we report ESBL‐producing Escherichia coli in wild common vampire bats Desmodus rotundus and livestock near Lima, Peru. Molecular analyses revealed that most of this resistance resulted from the expression of blaCTX‐M‐15 genes carried by plasmids, which are disseminating worldwide in hospital settings and have also been observed in healthy children of Peru. Multilocus sequence typing showed a diverse pool of E. coli strains carrying this resistance that were not always host species‐specific, suggesting sharing of strains between species or infection from a common source. This study shows widespread ESBL resistance in wild and domestic animals, supporting animal communities as a potential source of resistance. Future work is needed to elucidate the role of bats in the dissemination of antibiotic‐resistant strains of public health importance and to understand the origin of the observed resistance.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Streicker, Dr Daniel and Benavides, Dr Julio
Authors: Benavides, J.A., Shiva, C., Virhuez, M., Tello, C., Appelgren, A., Vendrell, J., Solassol, J., Godreuil, S., and Streicker, D.G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Zoonoses and Public Health
Publisher:Wiley
ISSN:1863-1959
ISSN (Online):1863-2378
Published Online:25 March 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Zoonoses and Public Health 65(4):373-463
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
634192Managing viral emergence at the interface of bats and livestockDaniel StreickerWellcome Trust (WELLCOTR)102507/Z/13/ZRI BIODIVERSITY ANIMAL HEALTH & COMPMED