Covalently attached antimicrobial surfaces using BODIPY: improving efficiency and effectiveness

Peveler, W. J. , Noimark, S., Al-Azawi, H., Hwang, G. B., Crick, C. R., Allan, E., Edel, J. B., Ivanov, A. P., MacRobert, A. J. and Parkin, I. P. (2018) Covalently attached antimicrobial surfaces using BODIPY: improving efficiency and effectiveness. ACS Applied Materials and Interfaces, 10(1), pp. 98-104. (doi: 10.1021/acsami.7b13273) (PMID:29210273)

Abstract

The development of photoactivated antimicrobial surfaces that kill pathogens through the production of singlet oxygen has proved very effective in recent years, with applications in medical devices and hospital touch surfaces, to improve patient safety and well being. However, many of these surfaces require a swell-encapsulation-shrink strategy to incorporate the photoactive agents in a polymer matrix, and this is resource intensive, given that only the surface fraction of the agent is active against bacteria. Furthermore, there is a risk that the agent will leach from the polymer and thus raises issues of biocompatibility and patient safety. Here, we describe a more efficient method of fabricating a silicone material with a covalently attached monolayer of photoactivating agent that uses heavy-atom triplet sensitization for improved singlet oxygen generation and corresponding antimicrobial activity. We use boron-dipyrromethane with a reactive end group and incorporated Br atoms, covalently attached to poly(dimethylsiloxane). We demonstrate the efficacy of this material in producing singlet oxygen and killing Staphylococcus aureus and suggest how it might be easily modifiable for future antimicrobial surface development.

• Item Type: Articles
• Additional Information: Donation of the fluorescence spectrometer was gratefully received from Richard H. Unthank. W.J.P. is recipient of an EPSRC Doctoral Prize Fellowship (EP/M506448/1). S.N. and C.R.C. acknowledge the Ramsay Trust for a Memorial Fellowship.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Peveler, Dr William
• Authors: Peveler, W. J., Noimark, S., Al-Azawi, H., Hwang, G. B., Crick, C. R., Allan, E., Edel, J. B., Ivanov, A. P., MacRobert, A. J., and Parkin, I. P.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: ACS Applied Materials and Interfaces
• Publisher: American Chemical Society
• ISSN: 1944-8244
• ISSN (Online): 1944-8252
• Published Online: 06 December 2017
• Copyright Holders: Copyright © 2017 American Chemical Society
• First Published: First published in ACS Applied Materials and Interfaces 10(1): 98-104
• Publisher Policy: Reproduced under a Creative Commons License