Axonal swellings and degeneration in mice lacking the major proteolipid of myelin

Griffiths, I. et al. (1998) Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science, 280(5369), pp. 1610-1613. (doi:10.1126/science.280.5369.1610) (PMID:9616125)

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Abstract

Glial cells produce myelin and contribute to axonal morphology in the nervous system. Two myelin membrane proteolipids, PLP and DM20, were shown to be essential for the integrity of myelinated axons. In the absence of PLP-DM20, mice assembled compact myelin sheaths but subsequently developed widespread axonal swellings and degeneration, associated predominantly with small-caliber nerve fibers. Similar swellings were absent in dysmyelinated shiverer mice, which lack myelin basic protein (MBP), but recurred in MBP*PLP double mutants. Thus, fiber degeneration, which was probably secondary to impaired axonal transport, could indicate that myelinated axons require local oligodendroglial support.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Yool, Professor Donald and Anderson, Professor Jim and Griffiths, Prof Ian
Authors: Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., and Nave, K.-A.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Science
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
ISSN (Online):1095-9203

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